何首乌对阿尔茨海默病大鼠学习记忆能力的作用

Effect of Polygonum Multiflorum Thumb on learning and memory capacity in mice with AD

目的:研究何首乌对阿尔茨海默病大鼠学习记忆能力的作用可能机制。方法:通过Y-迷宫观察何首乌对吗啡成瘾小鼠学习与记忆能力的影响,观察海马形态研究何首乌对海马CA1区神经元的影响。结果:何首乌硫浸膏治疗组与原发性痴呆症模型组大鼠的分辨学习及记忆保持能力有显著差异,小鼠海马CA1区神经元细胞数差异显著。结论:何首乌对阿尔茨海默病大鼠的学习记忆有保护作用,其具体机制可能与其抑制海马细胞凋亡有关。

Objective：To study the effect of Polygonum Multiflorum Thumb on the learning and memory capacity of mice with AD and its possible mechanism.Methods：weobserved the effect of Polygonum Multiflorum Thumb on the learning and memory capacity of mice with AD through Y-maze and CA1 area of hippocampal neurons by morphology.Results：Polygonum Multiflorum Thumb treatment group showed significant differences in the learning,memory capacity and the CA1 area cell number of hippocampal neurons,compared with morphine withdrawal group.Conclusion：Polygonum Multiflorum Thumb protects the learning and memory capacity of mice with AD,which may be related to the inhibition of the apoptosis of hippocampus.