早期胰岛素治疗对糖尿病大鼠心肌功能的干预作用

Effect of myocardial function in diabetic rats with early insulin treatment

目的探讨速度向量成像（VVI）技术结合负荷超声心动图评价早期应用胰岛索对糖尿病（DM）大鼠心肌功能的干预作用。方法30只大鼠中20只腹腔注射链脲佐菌素复制糖尿病模型，其余10只作为对照组。糖尿病大鼠成模后又随机分为DM组（10只）和治疗组（10只），治疗组每天给予皮下注射胰岛素。每只大鼠分别进行基础和潘生丁负荷VVI检查。结果静息状态下DM组和治疗组各项VVI指标均低于对照组，治疗组的收缩期最大速度、切向应变及收缩与舒张期最大切向应变率均较DM组明显提高；各项VVI心肌功能储备指标三组间比较差异均有统计学意义，并且治疗组的各项储备指标与DM组比较均显著增加。结论胰岛素的早期应用可以改善糖尿病大鼠心肌功能。

Objective To assess the myocardial function with early insulin treatment by velocity vector imaging （VVI） combined with dipyridamole stress in diabetic rats. Methods The 30 rats comprised 20 diabetic rats and 10 normal rats in the study. The 20 diabetic rats were divided into the diabetes mellitus （DM） group and the treatment group. Every rat in the treatment group was hypodermic injected with protamime biosynthetic human insulin after the diabetic model established. The control group was including 10 normal rats of the same age. After 8 weeks, each rat was performed with VVI at baseline and after dipyridamole stress. Results At baseline VVI,the parameters in the DM and the treatment groups were reduced compared with those in the control group. The systolic velocity, circumferential strain, systolic and diastolic circumferential strain rate in the treatment group were increased significantly compared with those in the DM group. After stress, the VVI reserve parameters in the treatment group were higher than those in the DM group. Conclusions The myocardial function are improved with early insulin treatment in the diabetic rats.