自血穴位注射治疗寻常型银屑病多中心疗效观察及对外周血IL-8、TNF-α的影响

Multicenter observation of curative effects of self-blood point injection on treating unusual type psoriasis and effects on IL-8 and TNF-α in peripheral blood

目的观察自血穴位注射治疗寻常型银屑病的临床疗效及对外周血白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)的影响。方法将200例寻常型银屑病患者随机分成治疗组100例和对照组100例,治疗组予自血穴位注射治疗,对照组静脉滴注复方甘草酸苷联合外用维A酸霜治疗。观察治疗前后外周血IL-8、TNF-α水平的变化及临床疗效。结果治疗组总有效率为85%,对照组为71%,2组比较差异有统计意义(P<0.05)。2组治疗前IL-8和TNF-α水平比较,差异无统计意义(P>0.05);2组同组治疗前后比较,治疗后IL-8和TNF-α水平显著降低,差异有统计意义(P<0.05);2组治疗后IL-8和TNF-α水平比较,差异无统计意义(P>0.05)。结论自血穴位注射治疗寻常型银屑病疗效显著,其对外周血IL-8、TNF-α的影响可能是其治疗银屑病的机制之一。

Objective To observe the curative effect of self-blood point injection on treating unusual type psoriasis and effects on IL-8 and TNF-α in peripheral blood.Methods 200 patients with unusual type psoriasis were randomly divided into treating group（n=100） and control group（n=100）.The treating group was treated by self-blood point injection,the control group was treated by intravenous drip of compound glycyrrhizin combined with topical tretinoin cream.The level of IL-8 and TNF-α in peripheral blood and clinical effect were observed before and after treating.Results The total effective rate of treating group was 85%,while that of control group was 71%,there was significant difference between these two groups（P0.05）.The difference of the level of IL-8 and TNF-α of these two groups before treating was not significant（P0.05）,the level of IL-8 and TNF-α of these two groups after treating was significantly lower than that before treating（P0.05）,the difference of these two groups after treating was not significant（P0.05）.Conclusion The curative effect of self-blood point injection is obvious on treating unusual type psoriasis,the effect of self-blood point injection on IL-8 and TNF-α in peripheral blood may be one mechanism of treating unusual type psoriasis.