应对方式与个性对Graves病发病的影响

Effect of coping styles and personality in etiology of Graves＇ disease

目的探索应对方式、个性特征对Graves病（GD）发病的影响，为预防Graves病提供流行病学依据。方法采用特质应对方式问卷（TCSQ）、艾森克人格问卷（EPQ）中文版对临床收集的581名Graves病患者及社区收集的800名健康对照收集资料，应用非条件logistic逐步回归分析进行整体分析，并按照年龄、性别、文化程度进行分层分析，探索应对方式与个性特征对Graves病发病的影响。结果整体分发现消极应对方式（OR=1．068，P=0．000）、掩饰性（OR=1．121，P=0．000）和内外向（OR=1．089，P=0．005）均为Graves病发病危险因素；按照性别、年龄和文化程度分层分析，其结果与整体分析结果基本一致，同时发现积极应对方式为Graves病发病保护因素（各分层分析中OR〈1．000，P〈0．05），神经质（OR〉1．000，P〈0．05）为部分人群Graves病发病危险因素。结论采取积极应对方式和针对性调整个性特征，可以有效预防Graves病发病。

Objective To explore the role of coping styles and personalities in the etiology of Graves＇ disease （GD）. Methods All participants （581 patients and 800 normal controls） completed the general information questionnaires, trait coping style questionnaires （TCSQ） and eysenck personality questionnaires revised, short scale for Chinese （EPQ-RSC）. Basic characteristics of all subjects were documented, and logistic regression analysis was used to analyze the role of coping styles and personality in etiology of GD. Results The negative coping style （ OR = 1. 068, P = 0. 000）, concealing character（ OR = 1. 121, P = 0. 000） and internal and external personality （ OR = 1. 089, P = 0. 005 ） neurotic personality （ OR 〉 1. 000, P 〈 0.05） were risk factors of GD （ OR = 1.162, P =0. 000）, positive coping style was protective factor of GD （ OR 〈 1. 000, P 〈 0.05 ）. Conclusion Positive coping style and specific personality adjustment can prevent effectively onset of GD.