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结直肠癌组织Toll样受体4和髓系分化蛋白88mRNA检测 被引量：3

Toll-like receptor4 mRNA and myeloid differentiation factor 88 in colorectal cancer
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摘要 目的通过检测结直肠癌组织Toll样受体4(TLR4)mRNA和髓系分化蛋白88(MyD88)mRNA,并分析其与分化、分期、转移的相关性,阐明TLR4和MyD88在结直肠癌发生发展中的作用。方法实时荧光定量PCR(RT-qPCR)检测62例结直肠癌和25例癌旁正常组织TLR4mRNA和MyD88mRNA。结果结肠癌组织TLR4mRNA、MyD88mRNA表达量明显高于癌旁组织(P<0.01)。低分化型结肠癌MyD88mRNA高于高、中分化结肠癌(P<0.01)。Dukes'A、B期TLR4mRNA和MyD88mRNA表达量低于C、D期(P<0.01)。结论结直肠癌TLR4、MyD88mRNA表达增加,并参与肿瘤的发生发展。 Objective To study the relationship between the increased expression of Toll-like receptors（TLR4） and myeloid differentiation factor 88（MyD88） mRNA in colorectal cancer tissue and the differentiation,stage and metastasis of colorectal cancer.Methods specimens of colorectal cancer and normal tissues adjacent to colorectal cancer were examined for TLR4mRNA and MyD88mRNA with the method of real-time qPCR.Results The TLR4mRNA and MyD88mRNA in colorectal cancer tissue were significantly higher than those in tissues adjacent to colorectal cancer（P0.01）.In addition,MyD88mRNA was significantly associated with differentiation status（P0.01）.Both MyD88mRNA and TLR4mRNA were significantly associated with Duck＇s stage（P0.01）,but was not associated with lymph node metastasis.Conclusion Increased expression of TLR4mRNA and MyD88mRNA in colorectal cancer tissue may play an important role in the carcinogenesis and progression of colorectal cancer.
作者 于月红 钱雷 陈玮
机构地区 滨海县人民医院检验科
出处 《海南医学》 CAS 2011年第12期9-11,共3页 Hainan Medical Journal
关键词 TOLL样受体4 结直肠癌 髓系分化蛋白88 Colorectal cancer Toll-like receptor4 Myeloid differentiation factor 88
分类号 R735 [医药卫生—肿瘤]
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参考文献11

  • 1Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity [J]. Cell, 2006, 124: 783-801.
  • 2Jemal A, Siegel R, Ward E, et al .Cancer statistics [J]. CA Cancer J Clin, 2009, 59: 225-249.
  • 3Wolpin BM, Mayer ILl Systemic treatment of colorectal cancer[J]. Gastroenterology, 2008, 134: 1296-1310.
  • 4Huang B, Zhao J, Unkeless JC, et al. TLR signaling by tumor and immune cells: a double-edged sword [J]. Oncogene, 2008, 27: 218-224.
  • 5Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer [J]. Nat Rev Cancer, 2009, 9: 57-63.
  • 6Bohnhorst J, Rasmussen T, Moen SH. Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia:Official Journal of the Leukemia Society of America [J]. Leukemia Research Fund, UK, 2006, 6: 228-234.
  • 7Takeda K, Kaisho T, Akira S. Toll like receptors [J]. Aunu Annu Rev Immunol, 2003, 21: 335- 376.
  • 8Lee S J, Lira KT. UDN glycoprotein regulates activities of activator protein-1, and nuclear factor-kB stimulated by reactive oxygen radicals in lipopolysaecharide-stimulated HCT-I16 cells [J]. Cancer Lett, 2007, 254: 274- 287.
  • 9He W, Liu Q, Wang L, et al .TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive eytokines and apoptosis [J]. Mol Immunol, 2007, 44(11): 2850-2859.
  • 10Earl TM, Nicoud IB, Pierce JM, et al.Silencing of TLR4 decreases liver tumor burden in a murine model of coloreetal metastasis and hepatic steatosis [J]. Ann Surg Oncol, 2009, 16: 1043-1050.

同被引文献49

  • 1AN HuaZhang,QIAN Cheng & CAO XueTao National Key Laboratory of Medical Immunology & Institute of Immunology,Second Military Medical University,Shanghai 200433,China.Regulation of Toll-like receptor signaling in innate immunity[J].Science China(Life Sciences),2010,53(1):34-43. 被引量：29
  • 2JUODELE L,JUOZAITYTE E, ZINDZIUS A, et al. Multi- ple endocrine neoplasia syndroms Type 1 [ J ]. Medicina ( Kaunas ), 2004,40 ( 5 ): 490 -504.
  • 3AGARWAL S K,P A KENNEDY,P C SCACHERI, et al. Menin molecular interactions:insights into normal func- tions and tumorigenesis [ J ]. Horm Metab Res, 2005,37 (6) : 369-374.
  • 4BERTOLINO P,RADOVANOVIC I, CASSE H, et al. Ge- netic ablation of the tumor suppressor menin causes le- thality at mid-gestation with defects in multiple organs [ J ]. Mech Dev ,2003,120 ( 5 ) :549-560.
  • 5POISSON A, ZABLEWSKA B, GAUDRAY P, et al. Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1 [ J ]. Cancer Lett, 2003,189(1) :1-10.
  • 6XU B, LI SH, ZHENG R, et al. Menin promotes hepatocel- lular carcinogenesis and epigenetically up-regulates Yapl transcription[J]. Proc Natl Acad Sci USA,2013 22,110 (43) : 17480-17485.
  • 7CIERPICKI T, GREMBECKA J. Challenges and opportu- nities in targeting the menin-MLL interaction [ J ]. Future Med Chem,2014 Mar,6(4):447-462.
  • 8WANG L Q, CHEN G, LIU X Y, et al. MicroRNA802 pro- motes lung carcinoma proliferation by targeting the tumor suppressor menin[ J]. Mol Med Rep,2014,10 ( 3 ) : 1537-1542.
  • 9FONTANIERE S, DUVILLIE B, SCHARFMANN R, et al. Tumour suppressor menin is essential for development of the pancreatic endocrine cells [ J ]. Endocrinol, 2008,199 (2) :287-298.
  • 10WATTERS T M,KENNY E F,ONEILL L A,et al. Struc- ture, function and regulation of the Toll/IL-1 receptor ada- ptor proteins [ J ]. Immunol Cell Biol, 2007,85 ( 6 ) : 411 - 419.

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海南医学
2011年 第12期

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