闭角型青光眼患者急性发作时角膜内皮细胞形态特征分析

Morphological characteristics of corneal endothelial cells in primary angle-closure glaucoma patients suffering acute attack

目的观察闭角型青光眼患者急性发作时角膜内皮细胞形态特征,以进一步探讨短期急性高眼压对角膜内皮细胞的损害机制。方法收集闭角型青光眼初次急性发作、发作持续时间在3d以内的患者20例20眼,选取老年性白内障患者20例20眼作为对照组。2组患者分别进行非接触型角膜内皮显微镜检查,比较2组患者的角膜内皮细胞最小细胞面积、最大细胞面积、平均细胞面积、细胞面积标准差、细胞面积变异系数、细胞密度和六角形细胞比例有无差异。结果青光眼急性发作组和对照组患者的角膜内皮细胞最小细胞面积、最大细胞面积、平均细胞面积、细胞面积标准差、细胞面积变异系数、细胞密度相比,差异均无统计学意义(均为P>0.05)。青光眼急性发作组角膜内皮细胞六角形比例为(48.0±13.9)%,对照组为(58.0±6.7)%,2组比较差异有显著统计学意义(t=-2.91,P=0.006)。结论短期持续高眼压会首先导致角膜内皮细胞的形状发生改变,而其他测量指标可能维持不变。

Objective To observe the morphological characteristics of corneal endothelial cells in primary angle-closure glaucoma（PACG）patients suffering acute attack,and further discuss the damage mechanisms of short-term high intraocular pressure on corneal endothelial cells.MethodsTwenty PACG patients suffering first acute attack with the duration in 3 days were enrolled,and 20 senile cataract patients were enrolled as the control group.All the patients were performed non-contact specular microscopy examination.The minimum cell area,maximum cell area,average cell area,standard deviation of cell area,coefficient of variation,cell density and percentage of hexagonal cells were analyzed and compared in two groups.ResultsThere was no statistical difference in minimum cell area,maximum cell area,average cell area,standard deviation of cell area,coefficient of variation and cell density between two groups（P0.05）.The percentage of hexagonal cells in the glaucoma group（48.0±13.9）% was lower than that in the control group（58.0±6.7）%,there was statistical difference（t=-2.91,P=0.006）.ConclusionFor the PACG patients suffering acute attack,the hexagonal shape of the corneal endothelium cells will be firstly changed,while the other corneal endothelial cell parameters can remain unchanged.