卤米松乳膏联合维A酸乳膏治疗掌跖脓疱病疗效观察

Analysis of the Efficacy of Halometasone Cream Combining with Tretinoin Cream on Treatment of Palmoplantar Pustulosis

目的观察卤米松乳膏联合维A酸乳膏治疗掌跖脓疱病的疗效及安全性。方法采用随机对照法将45例患者分为两组,治疗组23例,外用卤米松乳膏2次/d,同时每晚外用0.1%维A酸乳膏1次;对照组22例,仅外用卤米松乳膏,用法同治疗组,疗程均为8周,治疗结束后判定疗效。结果治疗组治疗2周、4周和8周时的有效率分别为17.39%,60.87%和82.61%,优于对照组的9.09%,27.27%和54.54%。两组患者治疗4周和8周时的有效率差异有统计学意义(P均<0.05)。且两组均未见严重不良反应。结论外用卤米松乳膏联合维A酸乳膏治疗掌跖脓疱病疗效好,安全性高。

Objective To observe the efficacy and safety of Halometasone combining with Tretinoin Cream on treatment of Palmoplantar Pustulosis. Methods A randomized controlled clinical observation was adopted in this study. Forty five patients were divided into two groups. Twenty three patients in the treatment group were treated with Halometasone Cream twice a day combining with Tretinoin Cream. Twenty two patients in control group were treated with Halometasone cream twice a day only. The efficacy was evalu- ated 8 weeks later. Results Effective ratio of the treatment group on the second week, the 4th week and the 8th week were 17.39% ,60.87% and 82.61% ,while that of the control group were 9.09% , 27.27% and 54.54%. There were statistical difference between the two groups on the 4 th week and the 8 th week（ all P 〈 0.05 ）. No serious side effect were observed both in two groups. Conclusion The results suggest that combination of halometasone cream and tretinoin cream is effective and safe in treatment of palmoplantar pustulosis.