肠促胰素的胰腺外作用研究进展

Progress in the studies on extra-islet effects of incretin

肠促胰素是经食物刺激后由肠道细胞分泌人血、能够刺激胰岛素分泌的一类激素。人体中，胰升糖素样肽1（GLP-1）和糖依赖性胰岛素释放肽（GIP）发挥肠促胰素效应。本文简要介绍肠促胰素的胰腺作用，重点回顾其胰腺外生理作用，以全面评价肠促胰素类药物的临床应用前景。

Incretin is defined as an intestinal hormone released in response to nutrient ingestion, which potentiates the glucose-induced insulin response. In human body, the incretin＇s effect is mainly induced by two peptide hormones, glucagon-like peptide-1 （ GLP-1 ） and glucose-dependent insulinotropic polypeptide （GIP）. In order to fully evaluate the clinical advantages of novel agents based on incretin, this review introduces the islet actions of incretin in brief, and mainlv focuses on the extra-islet effect of incretin.