期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

五环三萜类柴胡皂苷单体抗耐红霉素金黄色葡萄球菌活性研究 被引量：3

Effect of monomers of pentaeyclic triterpennoids of saikosaponines from Bupleurum kunmingense against erythromycin-resistant staphylococcus aureus
下载PDF
导出
摘要 目的探讨柴胡抗菌有效成分五环三萜类活性单体Bp3的抗耐红霉素金黄色葡萄球菌(ERSA)作用及其与红霉素的协同作用。方法参照美国临床实验室标准化委员会标准,测定Bp3对20株ERSA的最低抑菌浓度值(MIC)及其与红霉素的协同作用。结果 Bp3对ERSA的抑菌作用优于红霉素,且联合用药时显著减少了每一药物的MIC。20株耐红霉素黄色葡萄球菌均表现为协同或相加作用方式。结论结构明确的五环三萜类单体Bp3对ERSA有一定的抑制作用,且与红霉素有协同或相加作用。 Objective To discuss the antimicrobial activity of monomers named pentaeyclic triterpennoids（Bp3）.Methods According to the Standard of National Committee for Clinical Laboratory（NCCLS）,the minimal inhibi-tory concentrations（MIC） of Bp3 on 20 erythromycin-resistance staphylococcus aureus（ERSA） and its effects with erythromycin detected by microdilution method and checkerboard microdilution method.Results The inhibitory ef-fect of Bp3 on ERSA was better than erythromycin.When Bp3 and erythromycin were given in combination,MIC significantly reduced.Conclusions Bp3 can inhibit ERSA to some extent,and the combination effect of Bp3 and er-ythromycin is better.
作者 姜淼 沈亮亮 叶元康 潘胜利 施伟民
机构地区 上海市同济医院 同济大学附属同济医院 复旦大学药学院 上海市第一人民医院
出处 《现代实用医学》 2011年第5期498-500,F0002,共4页 Modern Practical Medicine
基金 国家新药筛选中心横向基金资助项目(HX0410)
关键词 中草药 单体 耐红霉素金黄色葡萄球菌 红霉素 体外抗菌活性 Traditional chinese medicine Monomers Erythromycin-resistant staphylococcus aureus Erythromycin In-vitro antibacterial activity
分类号 R91 [医药卫生—药学]
  • 相关文献

参考文献6

  • 1From the centers for disease control and prevention.Foujr pediatric deaths from community-acquired methicillin-resistant staphylococcus aureus-Minnesota and North Dakota[J].JAMA,1999,282(12):1123-1125.
  • 2赵江花,杨健英,赵文申,马红英,张健敏.259例金黄色葡萄球菌对红霉素、克林霉素的诱导耐药性研究[J].中国实用医药,2008,3(27):37-38. 被引量：8
  • 3Inducible clindamycin resistance among clinical isolates of Staphylococci[J].India J pathol Microbiol,2009,52(1):49-51.
  • 4Harbarth S,Fankhauser C,Schrenzel J,et al.Universal screening for methicillin-resistant staphylococcus aureus at hospital admission and nosocomial infection in surgical patients[J].JAMA,2008,299(10):1149-57.
  • 5沈亮亮 叶元康.致病性真菌体外药物敏感性实验的方法.同济大学学报：医学版,2004,25:96-99.
  • 6沈亮亮,叶元康.氟康唑与5-氟胞嘧啶体外联合抗白念珠菌临床分离株的研究[J].同济大学学报（医学版）,2005,26(6):19-21. 被引量：10

二级参考文献10

  • 1[1]Centers for disease control and prevention.Foujr pediatric deaths from community-acquired methicillin-resistant staphylococcus aureus minnesota and North Dakota.JAMA,1999,282,1123-1125.
  • 2[2]National Committee for Clinical Laboratory standards.Performance standards for antimicrobial susceptibility testing.Fourteenth informational supplement.NCCLs document M100-514.Wayne Pennsyivania:NCCLs,2004:40-47.
  • 3[3]Ledercq R.Mechanisms of resistance to macrokdes and lincosamides:nature of the resistance dements and their clinical implications.Clin Infect Dis,2002,34(4):4842-492.
  • 4[4]Fiebelkorn KR,Crawford SA,McElmeel ML,etal.Practical disk diffusion method for detection of inducible clindamycin resistance in staphylococcus aureus and coagulase-negative staphylococci.J Clin Microbiol,2003,41(10):4740-4744.
  • 5Citak S,Ozcelik B,Cesur S,Abbasoglu U.In vitro susceptibility of Candida species isolated from blood culture to some antifungal agents [ J ].Jpn J Infect Dis,2005 ,58(1) :44- 6.
  • 6Makimura K,Oguri T,Mikami Y,et al.Multicenter evaluation of commercial frozen plates for microdilution broth antifungal susceptibility testing of yeasts and comparison of MIC limits recommended in NCCLS M27- A2 [ J ].Microbiol Immunol,2005,49(2) :97-106.
  • 7van de Sande WW,Luijendijk A,Ahmed AO,et al.Testing of the in vitro susceptibilities of Madurella mycetomatis to six antifungal agents by using the Sensititre system in comparison with a viability - based 2,3 - bis ( 2 -methoxy- 4 - nitro- 5 - sulfophenyl) - 5 - [ (phenylamino) carbonyl ] - 2H - tetrazolium hydroxide (XTT)assay and a modified NCCLS method[J].Antimicrob Agents Chemother,2005 ,49(4):1364 - 1368.
  • 8Uchida K,Nishiyama Y.In vitro antifungal activity of luliconazoleJ(NND- 502),a novel imidoazole antifungal agents[J].Infect Chemother,2004,10(4) :216 - 219.
  • 9Berthet N ,Faure O ,Bakri A,et al.In vitro susceptibility of Aspergillus spp,clinical isolates to albendazole[J].J Antimicrob Chemother,2003 ,51 (6):1419 - 1422.
  • 10郭秀军,廖万清,任大明,徐红.氟康唑与5-氟胞嘧啶体外联合抗新生隐球菌临床分离株的实验研究[J].中国中西医结合皮肤性病学杂志,2003,2(2):91-93. 被引量：1

共引文献16

同被引文献69

  • 1陈一强,覃雪军,朱莲娜,宋志军,施焕中,闫萍,郭向华.金银花水煎液及联合头孢他啶对铜绿假单胞菌生物膜的体外影响[J].中华微生物学和免疫学杂志,2004,24(9):738-742. 被引量：37
  • 2熊英,傅颖媛,况南珍,张文平.黄芩苷抗白念珠菌作用及机制研究[J].中国药理学通报,2004,20(12):1404-1407. 被引量：72
  • 3曾春晖,杨柯,林启云,赵一.广西藤茶提取物APS抗菌作用研究[J].广西医学,2007,29(8):1238-1239. 被引量：8
  • 4梁恒兴,宝福凯,董晓萍,吕青,程永现.鹅不食草中具有抗菌活性的三萜类成分(英文)[J].云南植物研究,2007,29(4):479-482. 被引量：8
  • 5Deng Y, Liu J, Peters BM, et al. Antimicrobial resistance investigation on Staphylococcus strains in a local hospital in guangzhou, china, 2001-2010[J]. Microb Drug Resist, 2015,21(1): 102-104.
  • 6Sun L M, Cheng AX, Wu XZ, et al. Synergistic mechanisms of retigeric acid B and azoles against Candida albicans[J].J Appl Microbiol, 2010,108(1):341.
  • 7Xu Y, Wang Y, Yan L, et al. Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole resistant [J].J Proteoe Res, 2009,8( 11):5296.
  • 8RukachaisirikulV, Kamkaew M, SukavisitD, etal.Antibacterial xanthonesfrom theleaveso fGarcinianigrolineata[J]. JNatProd,2003,66(12): 1531-1535.
  • 9Cushnie TP, Lamb AJ. Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcusau-reus [J] .Phytomedicine, 2006,13(3):187-191.
  • 10DE SOUZA EL, DE BARROS JC, DE OLIVERIRA CE, etal. Influence of origanu vulare L. Essential oil n enterotoxin production, membrane permeability and surface characteristics ofStaphylococus aureus[J]. Int JFood Microbiol, 2010,137(3): 308-311.

引证文献3

二级引证文献30

现代实用医学
2011年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部