广东产千里光生物碱类成分研究

Studies on the Alkaloids of Senecio scandens Growing in Guangdong

目的:研究广东产千里光中生物碱类化学成分。方法:采用高分离度快速液相-质谱联用法(RRLC-ESI-MS/MS)对广东产千里光中生物碱类成分进行分析;采用硅胶柱层析法分离纯化获得克氏千里光碱单体,并对其进行了结构鉴定。结果:RRLC-ESI-MS/MS分析表明,广东产千里光药材含有野百合碱、阿多尼弗林碱、脱氢克氏千里光碱和克氏千里光碱4个生物碱类成分;其中,克氏千里光碱在广东产千里光中系首次发现。结论:广东产千里光的主要成分是克氏千里光碱。

Objective：To study alkaloids of Senecio scandens growing in Guangdong.Methods：The rapid resolution liquid chromatography-electrospray ionization mass spectrometry（RRLC-ESI-MS/MS）was used to analyse alkaloids of Senecio scandens growing in Guangdong,and senkirkine was isolated and purified by silica gel column chromatography.Results：Four alkaloids were identified as senkirkine,dehydrosenkirkine,monocrotaline and adonifoline,and senkirkine was firstly isolated from Senecio scandens growing in Guangdong.Conclusion：Senkirkine is the main component of Senecio scandens growing in Guangdong.