慢性心衰患者血清胆碱酯酶水平的变化及临床意义

Clinical significance of serum cholinesterase in patients with chronic heart failure

目的探讨慢性心力衰竭患者血清胆碱酯酶水平的变化规律及其临床意义。方法慢性心衰患者132例,按纽约心脏学会(NYHA)心功能分级分为三组:心功能Ⅱ级组44例;心功能Ⅲ级组38例;心功能Ⅳ级组50例。再按左室射血分数(LVEF)值分为两组:LVEF≥50%组59例和LVEF<50%组73例。所有病例入院第2天清晨检测血清胆碱酯酶水平。结果与心功能Ⅱ级患者对比,心功能Ⅲ级及心功能Ⅳ级患者的血清胆碱酯酶水平明显降低(P<0.01)。与LVEF≥50%患者对比,LVEF<50%患者的血清胆碱酯酶水平明显降低(P<0.01)。结论血清胆碱酯酶水平可以作为一个评价心功能的客观指标。

Objective To investigate the changes of cholinesterase in patients with chronic heart failure（CHF） and its significance. Methods A total of 132 patients with chronic heart failure according to NYHA classification into three groups：class Ⅱ（n=44）,class Ⅲ（n=38） and class Ⅳ（n=50）.And 132 patients were also divided into two groups according to left ventricular ejection fraction（LVEF）：LVEF≥50% group（n=59）and LVEF〈50% group（n=73）.Cholinesterase levels were detected at day 2 after admission in all patients. Results The level of cholinesterase in patients with function class Ⅲ-Ⅳ were significantly lower than those with function class Ⅱ（P〈0.01）.The level of cholinesterase in patients with LVEF≥50%was significantly higher than that in patients with LVEF〈50%（P〈0.01）. Conclusion Serum cholinesterase level can be used as an objective indicator to evaluate the cardiac function.