Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by 31P NMR and ESI-MS/MS
Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by 31P NMR and ESI-MS/MS
摘要
The reaction of amino acids and phosphorus trichloride in THF was studied by 31P NMR tracing and ESI-MS/MS. A series of hydridophoranes and cyclic dipeptides were obtained. The reaction presented interesting diversity and the reaction mechanism was proposed. The mechanism suggests that phosphorus plays an important role in the synthesis of amino acid hydridophorane and cyclic dipeptides. The results also show that 31P NMR and ESI-MS/MS are useful tools for the investigation of reaction mechanism.
The reaction of amino acids and phosphorus trichloride in THF was studied by 31P NMR tracing and ESI-MS/MS. A series of hydridophoranes and cyclic dipeptides were obtained. The reaction presented interesting diversity and the reaction mechanism was proposed. The mechanism suggests that phosphorus plays an important role in the synthesis of amino acid hydridophorane and cyclic dipeptides. The results also show that 31P NMR and ESI-MS/MS are useful tools for the investigation of reaction mechanism.
基金
Project supported by the National Natural Science Foundation of China （Nos. 20672104, 20732004）
参考文献37
-
1Fox, S. W. The Origins of Prebiological Systems and Their Molecular Matrices, Academic Press, New York, 1965, p. 289.
-
2Rabinowitz, J.; Flores, J.; Krebsbach, R.; Rogers, G. Nature 1969, 224, 795.
-
3Rabinowitz, J. Helv. Chim. Acta 19119, 52, 2663.
-
4Inoue, H.; Baba, Y.; Furukawa, T.; Maeda, Y.; Tsuhako, M. Chem. Pharm. Bull. 1993, 41, 1895.
-
5Tsuhako, M.; Fujita, N.; Nakahama, A.; Matsuo, T.; Kobayashi, M.; Ohashi, S. Bull. Chem. Soc. Jpn. 1980, 53, 1968.
-
6Tsuhako, M.; Fujita, N.; Nakahama, A.; Matsuo, T.; Kobayashi, M.; Ohashi, S. Bull. Chem. Soc. Jpn. 1981, 54, 289.
-
7Tsuhako, M.; Ohashi, S.; Nariai, H.; Motooka, I. Chem. Pharm. Bull. 1982, 30, 3882.
-
8Tsuhako, M.; Nakajima, A. Bull. Chem. Soc. Jpn. 1985, 58, 3092.
-
9Zhao, Y. F.; Ju, Y.; Li, Y. M.; Wang, Q.; Yin, Y. W.; Tan, B. Int. J. Peptide Protein Res. 1995, 45, 514.
-
10Ju, Y.; Zhao, Y. F.; Sha, Y. W.; Tan, B. Phosphorus Sulfur Silicon 1995, 101, 117.
-
1陈继承,潘廷跳,庞杰,何国庆.食醋中环苯丙-脯二肽快速检测方法研究[J].中国食品学报,2012,12(10):203-207. 被引量：2
-
2Binary Reaction Mechanism of ^(28)Si+^(24)Mg at 156.3 MeV[J].IMP & HIRFL Annual Report,1995(0):128-129.
-
3Dynamical Evolution of Reaction Mechanism for Collisionof^(40)Ar +^(58)Niat 25 MeV/u[J].IMP & HIRFL Annual Report,1997(0):15-16.
-
4程璐,缪铭,张涛,江波,沐万孟.食品生物防腐剂——抗真菌乳酸菌研究进展[J].食品与发酵工业,2010,36(9):129-133. 被引量：14
-
5方芳,吴奇辉,郭慧,蒋益虹.紫色马铃薯皮花色苷的结构鉴定[J].现代食品科技,2014,30(5):92-97. 被引量：9
-
6Dependence of Heavy Ion ReactionMechanism on Isospin Effect[J].近代物理研究所和兰州重离子加速器实验室年报：英文版,1999(1):116-116.
-
7张艳荣,樊红秀,刘婷婷,刘鸿铖.环(组氨酸-脯氨酸)二肽的高温高压辅助合成工艺优化（英文）[J].食品科学,2016,37(8):18-25. 被引量：3
-
8陈同新,刘宪俊,张立威.水溶剂法合成N-月桂酰基谷氨酸钠[J].口腔护理用品工业,2011,21(5):29-32. 被引量：2
-
9俞乐,丛芳,王兴国,金青哲,姜元荣.不同来源大豆毛油磷脂组成的核磁检测及磷脂酸含量比较[J].中国油脂,2017,42(1):130-133. 被引量：9
-
10杜成堂,庄东青,施波.核磁共振磷谱在羟基亚乙基二磷酸合成中的应用[J].波谱学杂志,2015,32(1):116-122. 被引量：5
