宫颈上皮内瘤病变HPV与Ki-67表达的相关性研究

A study about dependablity and expression of Ki-67 and HPV in the cervical intraepithelial neoplasia cancerization

目的:探讨人类乳头瘤病毒(HPV)、增殖细胞核蛋白(Ki-67)在宫颈上皮内瘤变中的表达状态,探讨其相关性及意义,以利于宫颈癌的防治和早期诊断。方法:选取宫颈活检病理确诊为CIN及宫颈鳞状细胞癌标本102例,应用免疫组化SP法检测Ki-67、原位杂交法检测高危HPV,并取正常宫颈组织进行对比研究。结果:在宫颈上皮内瘤变组织中Ki-67与HPV间的表达具有高度相关性(P<0.01)。结论:Ki-67在宫颈鳞癌中的高度表达与HPV感染有关,可作为有价值的诊断指标应用于宫颈癌高危人群筛查。

Objective： To analyses the significance and the dependablity the expression of Ki - 67 and high risk human papilloma virus （HPV） in the cervical intraepithelial neoplasia cancerization, as to provide the valuable for the early clinical diagnosis and early therapy. Methods：We choosed 102 CIN or cervix uteri squamous carcinoma samples which were final diagnosised by cervical biopsy. We detected Ki -67 and HPV by immunizing histo- chemistry and hybridization in situ respectively. At the same time we choosed normal cervix tissues samples as the control group. Results：There were siginificant correlations between the expression of Ki - 67 and HPV. Conclusion：The expression of Ki -67, In CIN siginificant con＇elated with HPV Infection. They may be as valuable for the diagnosis of cervical cancer screening high - risk groups.