快速测定布洛芬不同剂型的溶出度

Determine the dissolution of different Ibuprofen preparation formulation quickly

目的：对布洛芬片剂、胶囊、颗粒剂的溶出度进行快速测定并比较。方法：采用紫外分光光度法测定。测定波长为222nm。溶出介质为pH7．2磷酸盐缓冲液。结果：布洛芬溶液在2．5～20μg／ml范围内，吸收度与浓度呈良好的线性关系，r=0．9994。样品精密度试验RSD为1．17％，样品供试液在8h内稳定，片剂、胶囊及颗粒剂30分钟的溶出度均大于75％。结论：本方法快速、简单可靠，三种不同剂型的布洛芬制剂溶出度均符合中国药典要求。

Objective： Determine the dissolution of different Ibuprofen preparation formulation quickly. Methods： UV determination. Determination wavelength ： 222 nm. pH 7.2 dissolution medium for PBS. Results： Ibuprofen in 2.5 - 20μg/ml solution, the degree of absorption and concentration was good linear relationship, r = 0. 9994. Test samples precision RSD 1.17%, the sample tests solution are stable in 8h. Conclusion：This method is simple, stable and reliable, specific and effective determination of Ibuprofen preparation formulation dissolution, the 3 batch preparation formulations are conforms to the pharmacopoeia＇s request.