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聚二磷酸腺苷核糖聚合酶-1在细胞死亡中的作用 被引量：1

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摘要 聚二磷酸腺苷核糖化是细胞应对DNA损伤、保持基因组完整的一种重要机制。负责催化该反应的酶-聚二磷酸腺苷核糖聚合酶-1(PARP-1)参与了DNA损伤导致的两种细胞死亡:细胞凋亡和细胞坏死。细胞凋亡时,PARP-1被caspase特异性地降解,产生氨基端的24 ku片段和羧基端的89 ku片段;而完整的PARP-1的过度活化会引起能量丧失而致细胞坏死。现对PARP-1在这两种死亡结局中的作用作一综述。
作者 金玮 吴萍
机构地区 安徽医科大学第六临床学院耳鼻咽喉科 安徽医科大学免疫学教研室
出处 《安徽医科大学学报》 CAS 北大核心 2011年第7期696-699,共4页 Acta Universitatis Medicinalis Anhui
关键词 细胞凋亡 DNA损伤
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学] R345 [医药卫生—基础医学]
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参考文献15

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同被引文献17

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安徽医科大学学报
2011年 第7期

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