青海藏族女性乳腺癌Ki67和nm23表达与预后的关系

Relationship of Ki67 and nm23 expressions and prognosis in Tibetan women with breast cancer

目的探讨Ki67和nm23在青海藏族女性乳腺癌的表达与临床病理的关系。方法采用SP免疫组化方法检测61例(A组)青海藏族女性乳腺癌石蜡包埋组织和82例(B组)乳腺增生病变中Ki67和nm23的表达。结果 A组Ki67和nm23蛋白阳性表达率分别为67.2%和65.6%,而B组分别为28.0%和90.2%(P<0.05)。Ki67表达与临床分期,腋窝淋巴结转移相关(P<0.05),nm23与临床分期、雌激素受体(ER)状态有关(P<0.05),而与肿瘤大小、病理类型、患者年龄、月经状况及孕酮受体(PR)状态无关。Ki67和nm23的蛋白表达无相关性。结论 Ki67高表达和nm23低表达与青海藏族女性乳腺癌的侵袭、转移及预后有关。

Objective To study the relationship of Ki67 and nm23 expressions and prognosis in Tibetan women with breast cancer.Methods The expressions of Ki67 and nm23 were detected with immunohistochemistry SP staining in 61 breast saples taken from women with breast cancer（group A） and 82 breast samples taken from women with breast hypertrophy.Results The expressions of Ki67 and nm23 were 67.2% and 65.6% in group A,respectively,which were significantly defferent from 28.0% and 90.2% in group B（P〈0.05）.Ki67 expression was correlated to clinical staging and liphnode metastasis（P〈0.05） and nm23 expression was correlated to clinical staging and estrogen receptor（ER） status（P〈0.05）,which were not to correlated to tumor size,pathological typing,age of patient,menstruation and progesterone receptor（PR） status.The expression of Ki67 was not correlated to that of nm23.Conclusion Ki67 overexpression and nm23 downexpression are associated with invasion,metastasis and prognosis of breast cancer in Tibetan women.