摘要
对于无法手术或手术后复发、转移的结肠癌,主要依靠氟尿嘧啶类、铂类和伊立替康等药物为主的化疗,但易产生耐药性。近年国际上出现的分子靶向治疗,为大肠癌的治疗开辟了一条新途径。抗血管内皮生长因子单抗和抗表皮生长因子受体单抗等分子靶向药物联合化疗,可以明显提高化疗效果,且耐受性较好。分子靶向治疗正在成为除手术、化疗和放疗以外治疗大肠癌的第4种方法。
For patients with unresectable or recurrent/metastatic colon cancer,chemotherapy with fiuoropyrimidines,cisplatin/oxaliplatin and irinotecan is the main treatment,but multi-drug resistance occurs very often.The molecular targeted therapy of colorectal cancer has developed rapidly all over world in recent years.Results of some multi-nation,multi-center,randomized clinical trials show that targeted medicine combined with chemotherapy is effective and the side effects are well-tolerable.So it has been the 4th alternative method in treating colorectal cancer excepting surgery,chemotherapy and radiotherapy.
出处
《兰州大学学报(医学版)》
CAS
2011年第2期69-73,78,共6页
Journal of Lanzhou University(Medical Sciences)