期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微小RNA及其与眼相关性疾病的研究进展 被引量：1

原文传递
导出
摘要 微小RNA是一种长约22个核苷酸的非编码小分子RNA，它可通过阻断蛋白质翻译或降解信使RNA来调控基因表达。近年来发现，多种微小RNA分别存在于角膜、晶状体、视网膜中，并且广泛参与眼部多种疾病的发生、发展，如视网膜母细胞瘤、脉络膜黑色素瘤、眼部新生血管性疾病、葡萄膜炎、眼部神经退行性疾病、视网膜色素变性、眼部发育异常等。
作者 陈弦 陈梅珠 徐国兴
机构地区 南京军区福州总医院眼科安徽医科大学福总临床医学院眼科福建医科大学福总临床医学院眼科 福建医科大学附属第一医院眼科
出处 《国际眼科纵览》 2011年第3期181-184,共4页 International Review of Ophthalmology
基金 全军医药卫生科研基金（08MA105）
关键词 微小RNA 眼疾病
分类号 R77 [医药卫生—眼科]
  • 相关文献

参考文献26

  • 1Ryan DG, Oliveira-Fernandes M, Lavker RM. MiRNAs of the mammalian eye display distinct and overlapping tissue specificity. Mol Vis, 2006, 12: 1175-1184.
  • 2Karah M, Peluso I, Marigo V, et al. Identification and character- ization of microRNAs expressed in the mouse eye. Invest Ophthal- tool Vis Sci, 2007, 48: 509-515.
  • 3Makarev E, Spence JR, Del Rio-Tsonis K, et al. Identification of microRNAs and other small RNAs from the adult newt eye. Mol Vis, 2006, 12: 1386-1391.
  • 4Frederikse PH, Donnelly R, Partyka LM. MiRNA and Dicer in the mammalian lens: expression of brain-specific miRNAs in the lens. Histochem Cell Biol, 2006, 126 : 1-8.
  • 5Arora A, Mckay G J, Simpson DA. Prediction and verification of miRNA expression in human and rat retinas. Invest Ophthalmol Vis Sci, 2007, 48 : 3962-3967.
  • 6Xu S, Witmer PD, Lumayag S, et al. MiRNAs (miRNA)tran- scriptome of mouse retina and identification of a sensory organ-spe- cific miRNA cluster. J Biol Chem, 2007, 282: 25053-25066.
  • 7Zhao JJ, Yang J, Lin J, et al. Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analy- sis. Childs Nerv Syst, 2009, 25: 13-20.
  • 8Mu G, Liu H, Zhou F, et al. Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retino- blastomas. Hum Pathol, 2010, 41 : 493-502.
  • 9Dalgard CL, Gonzalez M, de Niro JE, et al. Differential miRNAs- 34a expression and tumor suppressor function in retinoblastoma ceils. Invest Ophthalmol Vis Sci, 2009, 50: 4542-4551.
  • 10Stark MS, Tyagi S, Nancarrow DJ, et al. Characterization of the melanoma miRNAome by Deep Sequencing. PLoS One, 2010, 5 : e9685.

同被引文献68

  • 1The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature,2012,489:57-74.
  • 2Mazzio EA, Soliman KF. Basic concepts of epigenetics:impact of environmental signals on gene expression. Epigenetics, 2012,7 : 119-130.
  • 3Waddington CH. The epigenotype. Endeavour, 1942,1 : 18-20.
  • 4Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol, 2010,28 : 1057-1068.
  • 5G6mez-Daz E, JordO M, Peinado MA, et al. Epigenetics of host- pathogen interactions:the road ahead and the road behind. PLoS Pathog,2012,8 : e1003007.
  • 6] Rao RC,Tchedre KT, Malik MT,et ah Dynamic patterns of histone lysine methylation in the developing retina. Invest Ophthalmol Vis Sci, 2010,51:6784-6792.
  • 7Perkel JM. microRNA Microarrays-Biocompare Editorial Article [ 2011-05-04 1. http://mimablog, com/microrna-microarrays- biocompare-editorial-article/.
  • 8Bhayani MK, Calin GA, Lai SY. Functional relevance of miRNA sequences in human disease. Mutat Res, 2012,731 : 14 - 19.
  • 9Li Y, Kowdley KV. MicroRNAs in Common Human Diseases. Genomics Proteomics Bioinformatics,2012,10:246-253.
  • 10Karali M, Peluso I, Gennarino VA, et al. miRNeye: a microRNA expression atlas of the mouse eye. BMC Genomics,2010,11:715.

引证文献1

二级引证文献7

国际眼科纵览
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部