CYFRA21-1对潮汕地区食管鳞状细胞癌的诊断价值

The expression of CYFRA21-1 in patients with esophageal squamous cell carcinoma in Chaoshan area

目的 探讨细胞角蛋白19片段（CYFRA21-1）在潮汕地区食管鳞状细胞癌诊断中的应用价值.方法 采用电化学发光法分别检测健康对照组（30例）和食管鳞状细胞癌患者（90例）术前、术后第10天血清中CYFRA21-1和癌胚抗原（CEA）浓度,并对患者进行随访,复发者再检测血清中CYFRA21-1和CEA浓度.结果 食管癌组术前CYFRA21-1和CEA水平明显高于对照组[分别为（5.13±2.75）μg/L比（1.61±0.70）μg/L,（3.14±1.60）μg/L比（1.93±0.74）μg/L,均P〈0.05].食管癌组术前CYFRA21-1和CEA水平高于术后第10天[分别为（5.13±2.75）μg/L比（2.44±0.65）μg/L,（3.14±1.60）μg/L比（2.55±0.92）μg/L],差异有统计学意义（均P〈0.05）.患者术前血清CYFRA21-1阳性率（58.9%,53/90）高于CEA（25.6%,23/90）,差异有统计学意义（χ2=18.00,P〈0.05）;复发者血清CYFRA21-1阳性率（72.5%,29/40）高于CEA（32.5%,13/40）,差异有统计学意义（χ2=12.50,P〈0.05）.结论 血清CYFRA21-1是食管鳞状细胞癌诊断和判断复发的辅助指标.

Objective To investigate the clinical significance of cytokeratin 19 fragments （CYFRA21-1）in patients with esophageal squamous cell carcinoma in Chaoshan area.Methods The electrochemiluminescence （ECLIA） was used to detect the serum concentrations of CYFRA21-1 and carcinoembryonic antigen（CEA）in the healthy controls and the patients with esophageal squamous cell carcinoma （ESCC） before surgery and 10 days after analyzed.Resuits In Chaoshan area.the serum levels of CYFRA21-1 and CEA in patients with ESCC were obviously higher before surgery than that 10 days after sugery（P〈0.05）.The positive rate of CYFRA21-1 before surgery（58.9%,53/90）was higher than that of CEA（25.6%,23/90）,with statistical significance（χ2=18.00,P〈0.05）.The positive rate of CYFRA21-1（72.5%,29/40）in the recurrence of esophageal tumors was higher than that of CEA（32.5%,13/40）,with statistical significance（χ2=12.50,P〈0.05）.Conclusion Serum CYFRA21-1 is the secondary indicator of the diagnosis and recurrence of ESCC.