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非酒精性脂肪性肝病与心血管疾病的临床相关性研究进展 被引量：3

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摘要 非酒精性脂肪性肝病(NAFLD)的发病率近年来逐步上升。此文就NAFLD导致心血管疾病(CVD)可能的机制以及NAFLD与CVD相关性的临床研究进展进行综述。作为CVD的高危人群,应对NAFLD患者予以足够的重视。在治疗NAFLD的同时积极预防CVD的发生具有重要的临床意义。
作者 常显星 俞丽芬
机构地区 上海交通大学医学院附属瑞金医院消化科
出处 《国际消化病杂志》 CAS 2011年第3期132-134,共3页 International Journal of Digestive Diseases
关键词 非酒精性脂肪性肝病 心血管疾病 游离脂肪酸 胰岛素抵抗
分类号 R575.5 [医药卫生—消化系统]
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参考文献6

  • 1Caserta CA, Pendino C-M, Amante A, et al. Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima media thickness in an adolescent population in southern Italy. AmJ Epidemiol, 2010, 171:1195-1202.
  • 2Sookoian S, Pirola CJ. Non alcoholc fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review. J Hepatol, 2008, 49:600-607.
  • 3Andreozzi F, Laratta E, Sciacqua A, et al. Angiotensin 1I impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells. CircRes, 2004, 94:1211-1218.
  • 4Targher G, Bertolini L, Rodella S, et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care, 2007, 30:2119-2121.
  • 5Chiang CH, Huang CC, Chan WL, et al. The severity of non alcoholic fatty liver disease correlates with high sensitivity C reactive protein value and is independently associated with increased cardiovascular risk in healthy population. Clin Biochem, 2010, 43:1399-1404.
  • 6Masahide Hamaguchi,Takao Kojima,Noriyuki Takeda,Chisato Nagata,Jun Takeda,Hiroshi Sarui,Yutaka Kawahito,Naohisa Yoshida,Atsushi Suetsugu,Takahiro Kato,Junichi Okuda,Kazunori Ida,Toshikazu Yoshikawa.Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease[J].World Journal of Gastroenterology,2007,13(10):1579-1584. 被引量：55

二级参考文献29

  • 1[1]Neuschwander-Tetri BA,Caldwell SH.Nonalcoholic steatohepatitis:summary of an AASLD Single Topic Conference.Hepatology 2003; 37:1202-1219
  • 2[2]Bellentani S,Saccoccio G,Masutti F,Croce LS,Brandi G,Sasso F,Cristanini G,Tiribelli C.Prevalence of and risk factors for hepatic steatosis in Northern Italy.Ann Intern Med 2000;132:112-117
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  • 9[9]Hamaguchi M,Kojima T,Takeda N,Nakagawa T,Taniguchi H,Fujii K,Omatsu T,Nakajima T,Sarui H,Shimazaki M,Kato T,Okuda J,Ida K.The metabolic syndrome as a predictor of nonalcoholic fatty liver disease.Ann Intern Med 2005; 143:722-778
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共引文献54

同被引文献22

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二级引证文献2

国际消化病杂志
2011年 第3期

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