腹腔给药治疗恶性腹水近期疗效观察

Effects of intra-abdominal phemotherapy for patients with malignant ascites

为了观察腹腔给药治疗60例恶性腹水的疗效,采用腹腔内注入抗癌药+复方苦参注射液的治疗方法。化疗药分别为5-氟尿嘧啶(5-FU)、顺铂(DDP)、卡铂及丝裂霉素,复方苦参注射液40～80 mL/次。结果卵巢癌并腹水有效率(10/14,71.4%)较高,其次为肝癌并腹水(2/5)及胃癌并腹水(4/20,25.0%),其他胰腺恶性肿瘤效果较差。总有效率为35.0%(21/60)。不良反应为消化道症状及轻度骨髓抑制。初步研究结果提示,用中西药联合的办法治疗恶性腹水,疗效明显,不良反应相对较轻。

The objecitve of this study was to observe the therapeutic effect of intra-abdominal chemotherapy. Sixty patients with malignant ascites were treated with intra-abdominal injection of anti-cancer drugs ＋ Compound kushen injection, and therapy drugs were 5-Fluorouracil （5-FU） ,Cisplatin （DDP）, Carbopiatin and Mitomycin, Com- pound kushen injection 40- 80 mL everytime. The effective rate of ascites patients with ovarian cancer was higher （10/14,71. 4%0）,ascites patients with hepatoma was 40.0% （2/5）, ascites patients with gastric cancer （4/20, 25.0%）, less effective for other pancreatic malignant tumors. Total effective rate was 35.0%（21/60）. The side effects were gastrointestinal symptoms and minor myelopoiesis inhibition. In conclusion, treatment of malignant ascites with combination of TCM and WM has a better curative effect, with fewer side effects.