nm23-H1与NGAL在宫颈癌中的表达与临床分析

Expression of nm23-H1 and NGAL Gene in Cervical Cancer

目的探讨nm23-H1、NGAL在宫颈癌中的表达与预后的关系。方法应用免疫组化SABC法检测100例宫颈癌中nm23-H1、NGAL的表达。结果宫颈癌中nm23-H1、NGAL的阳性率分别为48%和61%。其中,nm23-H1在不同年龄分组、临床分期和病例类型中阳性表达率差异无统计学意义(P>0.05);在有肿瘤转移的标本中阳性率为67.86%,低分化标本中阳性率为76.19%,肿瘤直径≥4cm标本中阳性率表达率56.52%,差异有统计学意义(P<0.05)。NGAL在不同临床分期和不同肿瘤直径组中阳性表达率无统计学意义(P>0.05);>45岁组标本中阳性率为70.49%,在鳞癌标本中阳性率为70.00%,在发生肿瘤转移的标本中阳性率为82.14%,在中高分化标本中阳性率为67.09%,差异有统计学意义(P<0.05)。结论 nm23-H1和NGAL的表达情况对宫颈癌的预后评估有一定的意义。

Objective To investigate the expression of nm23-H1 and NGAL gene in cervical cancer and its effect on the development of the cervical cancer. Methods The expression of nm23-H1, NGAL gene in 100 cases cervical cancer were studied with SABC immnnohistochemcal technique. Results In cervical cartcer, the positive expression rate of nm23-H1 and NGAL were 48% and 61%. The positive expression rate of nm23-H1 have no differences in different age groups, clinical stage and type of cases （P 〉 0.05 ）. The positive expression rate of nm23-H1 in the tumor metastasis, poor differentiation and tumor diameter ≥ 4cm specimens are high positive expression rate, respectively, 67.86%, 76.19% and 56.52%, the difference in their respective groups was significant（ P 〈 0.05 ）. There were no differences in positive expression rate in different clinical stages and different tumor size groups of NGAL （ P 〉 0.05 ）. NGAL have more positive expression rate in 〉 45-year-old group, squamous cell carcinoma, tumor metastasis, high differentiation and tumor diameter ≥ 4cm specimens, respectively,70.49%, 70.00%, 82.14% and 67.09%, the difference in their respective groups were significant （ P 〈 0.05 ）. Conclusion The positive expression rate of nm23-H1 and NGAL in the prognosis of cervical cancer have a certain significance.