纳洛酮联合氨茶碱及山莨菪碱对新生儿窒息复苏后的作用

The Clinical Effects of Naloxone Combined with Aminophylline and Anisodamine on Newborns after Resuscitation

目的探讨盐酸纳洛酮联合氨茶碱及山莨菪碱在新生儿窒息复苏后的临床疗效及临床应用价值,为新生儿窒息复苏后的临床治疗探索一种更为有效的治疗方法。方法根据Apgar评分标准,从我院2008年1月～2010年8月住院的窒息复苏后新生儿中,选取符合诊断标准的患儿60例,随机等分为对照组和实验组。治疗过程中两组均采用常规治疗方法,实验组在此基础上,给予纳洛酮、山莨菪碱及氨茶碱治疗。观察两组拥抱反射恢复正常的时间、完全脱离氧气治疗的时间及住院时间等。结果实验组完全恢复拥抱反射的时间明显短于对照组(P<0.01);实验组完全脱离氧气治疗的时间明显短于对照组(P<0.01);实验组平均住院天数较对照组明显减少(P<0.01)。结论盐酸纳洛酮联合氨茶碱及山莨菪碱在新生儿窒息复苏后的治疗中疗效显著,临床应用价值较高。

Objective To study the effects and clinical value of naloxone, aminophylline and anisodamine as adjuvant therapy on newborns after resuscitatiion. Methods Selected 60 cases by control program of newborns after resuscitation in children diagnostic criteria from our hospital from January 2008 to August 2010. 60 cases of newborns with resuscitation were randomly divided into two groups： control group and treatment group. In both groups, children in both groups had no significant difference in the sex, age, clinical manifestations and organ dysfunction. The common methods were taken in both groups. In the group treatment, naloxone, aminophylline and nisodamine was added, under Evaluation standard, the differences of recovery rate and hospital day of infants between two groups were compared by t test or chi-square test. Results The recovery time of embrace reflex of group treatment was much shorter than that of group control （ P 〈 0.01 ） ; The time from oxygen therapy of group treatment was much shorter than that of group control （ P 〈 0.01 ） ; The hospital day of group treatment was much less than that of group control （P 〈 0.01 ）. Conclusion Naloxone, aminophylline and anisodamine have the significant clinical effects on healing the newborns after resuscitation; Naloxone, aminophylline and anisodamine have the significant economic effectiveness and clinical aF, plication on healing the the newborns after resuscitation.