期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PI3K/Akt信号传导通路及其在结直肠癌中的研究进展 被引量：5

PI3K/Akt signaling pathway and its advances in colorectal cancer
下载PDF
导出
摘要 结直肠癌是常见的恶性肿瘤之一,近十年来,结直肠癌在我国的发病率呈逐年上升的趋势。已有研究表明,PI3K/Akt信号传导通路是与细胞增殖和细胞凋亡关系最密切的信号传导通路之一。随着PI3K/AKt信号通路在结直肠癌发生、发展中的研究不断深入,该通路对结直肠癌发生、发展及治疗药物的研发具有十分重要的价值。本文就PI3K/Akt信号传导通路在结直肠癌发生、发展和治疗中的作用以及机制的研究进展作一综述。 Colorectal cancer is one of the common malignant tumors.During the recent 10 years,the incidence of colorectal cancer has shown increasing trend in China.It has been demonstrated that PI3K/Akt signaling pathway is one of the most crucial pathways involved in cell proliferation and apoptosis in malignant tumor development.With the research of PI3K/Akt signaling pathways in colorectal cancer,it has very vital value in colorectal cancer occurrence and development.In this review,we briefly summarize advances of PI3K/Akt signaling pathways in colorectal cancer.
作者 肖秀英 于宝华
机构地区 上海市徐汇区中心医院肿瘤科 复旦大学附属肿瘤医院病理科
出处 《临床肿瘤学杂志》 CAS 2011年第6期558-561,共4页 Chinese Clinical Oncology
基金 上海市卫生局青年科研课题资助项目(2008Y087) 江苏大学临床医学科技发展基金资助项目(20080090)
关键词 PI3K/AKT信号传导通路 结直肠癌 PI3K/Akt signaling pathways Colorectal cancer
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

参考文献7

  • 1Wang J,Yang L,Yang J,et al.Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells[J].Cancer Res,2008,68(9):3152-3160.
  • 2Liao CH,Sang S,Ho CT,et al.Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src,ERK,and Akt survival signaling in human colon cancer cells[J].J Cell Biochem,2005,96(1):155-169.
  • 3Stahtea XN,Roussidis AE,Kanakis I,et al.Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation,MT1-MMP expression and pro-MMP2 activation[J].Int J Cancer,2007,121(12):2808-2814.
  • 4Reif K,Okkenhaug K,Sasaki T,et al.Cutting edge:differential roles for phosphorinositide 3-kinases,p110gamma and p110delta,in lymphocyte chemotaxis and homing[J].J Immuno,2004,173(4):2236-2240.
  • 5Dorrello NV,Peschiaroli A,Guardavaccaro D,et al.S6K1-and beta TRCP-mediated degradation of PDCD4 promotes protein translation and cell growth[J].Science,2006,314(5798):467-471.
  • 6Agarwal A,Das K,Lerner N,et al.The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin[J].Oncogene,2005,24(6):1021-1031.
  • 7ZHANG Yu-hua,WEI Wei,XU Hao,WANG Yan-yan,WU Wen-xi.Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways[J].Chinese Medical Journal,2007(9):743-748. 被引量：13

二级参考文献10

  • 1Jemal A,Siegel R,Ward E,Murray T,Xu J,Smigal C, etal.Cancerstatistics,2006[].CACancerJClin.2006
  • 2Todd W Bauer MD,Fan Fan,BS,et al.Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cellsrequires activation of c-met and urokinase plasminogen activator re-ceptor[].Annals of Surgery.2005
  • 3Kaio E,Tanaka S,Kitadai Y,Sumii M,Yoshihara M,Haruma K,Chayama K.Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma[].Oncology.2003
  • 4Carmeliet P,Jain R K.Angiogenesis in cancer and other diseases[].Nature.2000
  • 5Takahashi Y,Kitadai Y,Bucana CD,Cleary KR,Ellis LM.Expression of vascular endothelial growth factor and its receptor,KDR,correlates with vascularity,metastasis,and proliferation of human colon cancer[].Cancer Research.1995
  • 6Leung, D.W,Cachianes, G,Kuang, W.J,Goeddel, D.V,Ferrara, N.Vascular endothelial growth factor is a secreted angiogenic mitogen[].Science.1989
  • 7Senger,DR,Galli,SJ,Dvorak,AM,Perruzzi,CA,Harvey,VS,Dvorak,HF.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid[].Science.1983
  • 8Cooke,SP,Boxer,GM,Lawrence,L,Pedley,RB,Spencer,DIR,Begent,RHJ,Chester,KA.A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: receptor complex[].Cancer Research.2001
  • 9Slomiany MG,Black LA,Kibbey MM,et al.IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma[].Biochemical and Biophysical Research Communications.2006
  • 10Calza,L,Giardino,L,Giuliani,A,Aloe,L,Levi-Montalcini,R.Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors[].Proceedings of the National Academy of Sciences of the United States of America.2001

共引文献12

同被引文献69

引证文献5

二级引证文献10

临床肿瘤学杂志
2011年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部