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结肠癌组织中MICA和ADAM10的表达及其相关性 被引量：3

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摘要 目的研究MHC I类相关分子A(MHC classⅠchain-related A,MICA)及ADAM10在结肠癌中的表达及其与临床病理学参数之间的关系,并探讨两者的相关性,为结肠癌细胞表面MICA蛋白脱落机制的研究提供组织学依据。方法应用免疫组织化学方法,采用SP法检测有完整资料的90例结肠癌组织及30例癌旁组织中MICA和ADAM10的表达差异。结果在癌组织和癌旁组织中,MICA蛋白表达阳性率分别为67.8%和7.1%,ADAM10蛋白表达阳性率分别为82.2%和20%,差异均具有显著性(P<0.01),并且与淋巴结转移有关(P<0.05),MICA与ADAM10表达呈负相关性(r=-0.258,P<0.05)。结论 MICA的表达降低与AD-AM10的表达升高,可能共同参与了肿瘤的免疫逃逸及肿瘤的转移;且ADAM10在膜型MICA的脱落机制中发挥重要作用。
作者 刘丹 田秀春 肖芹 王翠梅 顾学文
机构地区 江苏省苏北人民医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2011年第6期652-654,共3页 Chinese Journal of Clinical and Experimental Pathology
关键词 结肠肿瘤 MHCI类相关分子A ADAM10 免疫组织化学
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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共引文献6

同被引文献75

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引证文献3

二级引证文献6

临床与实验病理学杂志
2011年 第6期

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