梅花钻对乙醇引起小鼠肝损伤的保护作用

Protective Effect of Kadsura heteroclite on Ethanol-induced Hepatotoxicity in Mice

目的:研究梅花钻对乙醇引起肝损伤的保护作用。方法:将昆明种小鼠分为正常对照组、乙醇模型组、梅花钻(33.40,16.70,8.35 g·kg-1)剂量组,观察各组小鼠血清的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、谷胱甘肽S-转移酶(GST)、超氧化物歧化酶(SOD)活性和肝匀浆中的丙二醛(MDA)、甘油三酯(TG)的含量,评价梅花钻对肝损伤的保护作用。结果:梅花钻高、中剂量组与乙醇模型组比较,ALT,AST,GST,MDA,TG降低(P<0.05或P<0.01),SOD明显升高(P<0.01)。结论:梅花钻对小鼠乙醇引起的肝损伤有保护作用。

Objective：To study the protective effect of Kadsura heteroclita（Roxb）Craib（KHC）on ethanol-induced hepatotoxicity in mice.Method： Mice were randomly divided into 5 groups to set up the model of hepatotoxicity by ethanol in mice：the normal,the ethanol model and 3 groups of KHC（33.40,16.70,8.35 g·kg-1）.The activities of alanine transaminase（ALT）,aspartate transaminase（AST）,glutathione s-transferase（GST）,superoxide dismutase（SOD）in serum and the contents of malondialdehyde（MDA）,triglyceride（TG）in liver were measured.Result： KHC（33.40,16.70 g·kg-1,qd×7）could reverse the activities of serum ALT,AST,GST,SOD and could decrease the contents of MDA,TG in liver.Conclusion： KHC showed effective protection on ethanol-induced hepatotoxicity.