中国人PDE4D基因(83T/C)多态性与缺血性脑卒中相关性的Meta分析

A Meta analysis on the association of PDE4D gene 83T/C polymorphism with ischemic stroke in Chinese population

目的综合评价中国人磷酸二酯酶4D（phosphodiesterase 4D,PDE4D）基因83T/C多态性与缺血性脑卒中发病的关系。方法利用Meta分析方法对国内外公开发表的有关中国人PDE4D基因83T/C多态性与缺血性脑卒中关系的研究文献进行综合定量分析。结果有6篇文献符合条件纳入研究,累积病例共1899例,累积对照组共2431例。Meta分析显示,以TT基因型为参照,携带CC基因型个体发生缺血性脑卒中危险性的OR值为1.53,95%,CI为1.22-1.91,Z=3.69,P〈0.05;携带CC或CT基因型的个体发生缺血性脑卒中的危险性的OR值为1.34,95%,C I为1.18-1.53,Z=4.48,P〈0.05;等位基因频数C/T的OR值为1.28,95%,CI为1.15-1.41,Z=4.75,P〈0.05。结论 PDE4D基因83T/C多态性与中国人缺血性脑卒中的发病具有相关性。

Objective To evaluate the relationship between phosphodiesterase 4D（PDE4D） gene 83T/C polymorphism and ischemic stroke（IS） among Chinese population.Methods A meta-analysis of studies published domestically and abroad about the relationship between PDE4D gene 83T/C polymorphism and IS was performed with comprehensive quantitative analysis.Results Based on the criterion,six papers were selected with a total of accumulative 1899 cases and 2431 controls.Meta-analysis results showed the OR value of ischemic stroke with CC genotype was 1.53（95% CI was 1.22~1.91）,Z=3.69,P0.05.The OR value of ischemic stroke with CC and CT genotype was 1.34（95% CI was 1.18~1.53）,Z=4.48,P0.05.The allele frequencies OR value of C/T was 1.28（95% CI为1.15~1.41）,Z=4.75,P0.05.Conclusion PDE4D gene 83T/C polymorphism is significantly associated with susceptibility of ischemic stroke in Chinese population.