氟康唑联合手术治疗真菌性角膜炎21例分析

Effect of Fluconazole combined with conjunctival flap covering surgery on fungal keratitis

目的:探讨氟康唑联合结膜瓣遮盖术治疗真菌性角膜炎的临床效果。方法:2008年4月～2010年4月我院眼科收治的确诊为真菌性角膜炎患者21例,在手术显微镜下行结膜瓣遮盖治疗,同时应用氟康唑全身及局部点眼抗真菌治疗。结果:所有患眼经上述治疗后角膜创面愈合,其中治愈18例,好转3例,无无效及恶化病例。随访6个月～1年,均无复发。术后视力:指数至0.4。结论:氟康唑联合结膜瓣遮盖术治疗真菌性角膜炎,具有经济有效、易操作、溃疡愈合快、无排斥反应等优点,值得基层医院推广应用。

Objective： To evaluate the clinical efficacy of fluconazole combined with conjunctival flap covering surgery on fungal keratitis.Methods： A total of 21 cases diagnosed as fungal keratitis in Ophthalmic Department of our hospital from April 2008 to April 2010,and were treated with conjunctival flap covering surgery and fluconazole eyedrops in systemic and local antifungal therapy.Results： A total of 18 cases were cured and 3 cases were improved.All patients were followed up for 6 months to 1 year,and no recurrence occurred.Visual acuity index of patients was 0.4.Conclusions： Fluconazole combined with conjunctival flap covering surgery is effective on fungal keratitis.It is economic,of easy operation,short recovery time and without reject reaction.It is worthy clinical application.