光接触过敏原与黄褐斑的相关性研究

Relationship between photoallergens and melasma

目的探讨常见光接触过敏原与黄褐斑之间的相关性。方法依循英国光学皮肤病研究组推荐的光斑贴试验操作步骤，从国家化妆品光感性皮炎诊断标准（GBl7149．6-1997）、国家化妆品接触性皮炎诊断标准（GBl7149．2-1997）及国家职业性皮肤病诊断标准（GBZl8-2002）中筛选出20种常见过敏原。对50例黄褐斑患者及30例正常人对照进行光斑贴试验。结果50例黄褐斑患者中光斑贴试验阳性24例占48．0％，30例正常人对照中光斑贴试验阳性7例占23．33％，黄褐斑患者光斑贴阳性率显著高于对照组（P〈0．05）。结论黄褐斑患者光斑贴试验阳性率高于正常人。

Objective To study the relationship between common photoallergens and melasma. Methods Twenty allergens were selected according to the National Diagnostic Criteria for Photosensitive Dermatitis induced by cosmetics, National Diagnostic Criteria for Contact Dermatitis induced by cosmetics and National Diagnostic Criteria for Occupational Skin Diseases. Based on the standard procedures for photopatch test recom- mended by the British Photodermatology Group （BPG）, photopatch test was performed on 50 patients with melasma and 30 normal controls. Results The positivity rate of photopatch test was 48.0% （24/50） in patients suffering from melasma, significantly higher than in the controls[23.33% （7/30）, P 〈 0.05 ]. Conclusion Patients with melasma appear more likely to have positive photopatch test than normal controls.