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银屑病性关节炎患者血清中转化生长因子-β1的检测 被引量：6

Measurement of transforming growth factor （TGF）-β1 in sera of patients with psoriatic arthritis
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摘要 目的探讨银屑病性关节炎患者血清中转化生长因子（TGF）-β1的表达及其意义。方法分别检测银屑病性关节炎患者与寻常性银屑病患者血清中TGF-β1的水平。结果38例银屑病性关节炎患者血清中的TGF-β1浓度为375．92±95．88pg／ml，80例寻常性银屑病患者为510．78±167．97pg／ml，两组差异有统计学意义（t=4．60，P〈0．01）。结论对银屑病性关节炎患者进行血清TGF-β1浓度的动态监测，有助于引起临床医师对银屑病性关节炎骨质疏松的警惕和预防。 Objective To measure the expression of TGF-β1 in the sera of patients with psoriatic arthritis and its significance. Methods The serum level of TGF-β1 was measured in 38 patients with psoriatic arthritis and 80 patients with psoriasis vulgaris. Results A significant difference was observed between the patients with psoriatic arthritis and those with psoriasis vulgaris （375.92 ± 95.883 pg/ml vs. 510.78 ±167.967 pg/ml, t = 4.60, P 〈 0.01）. Conclusion Continuous monitoring of serum levels of TGF-β1 may help clinicians to take precautions against osteoporosis in patients with psoriatic arthritis.
作者 杨雁 杨静 段西凌 李薇
机构地区 四川大学华西医院皮肤科 四川省人民医院皮肤性病研究所 四川省人民医院临床检验中心
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2011年第7期513-514,共2页 Chinese Journal of Dermatology
基金 四川省卫生厅科研基金（303005002154013）
关键词 血清TGF-Β1 转化生长因子-Β1 银屑病性关节炎 关节炎患者 检测 银屑病患者 动态监测 骨质疏松
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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  • 1Erlebacher A, Dervnck R. Increased expression of TGF-beta 2 in osteoblast results in osteoporosis-like phenotype [ J ]. J Cell Biol, 1996, 132(1/2) : 195-210.
  • 2Kim CH, Kim YH, Kim YK, et al. IL-1 beta induces and TGF-beta reduces vitamin D3-induced bone resorption in mouse ealvaial bone cells [J]. J Immunol Invest,2003,32 (3) :171-186.
  • 3Gao J, Symons Al, Bartold PM. Expression of transforming growth factor-betal (TGF -β1 ) in the developing periodontium of rats [J]. J Dent Res, 1998, 77(9) :1708-1716.
  • 4Kassem M, Kveiborg M, Eriksen EF. Production and action of transforming growth factor-beta in human osteoblast cultures:dependence on cell differentiation and modulation by calcitriol [J]. Eur J Clin Invest, 2000, 30(5) : 429-437.
  • 5Ueta C, Iwamoto M, Kanatani N, et al. Skeletal malformations caused by overexpression of Cbfal or its dominant negative form in chondrocytes [J]. J Cell Biol, 2001,153(4) : 87-100.
  • 6Gazit D, Zilberman Y, Ebner R, et al. Bone loss(osteopehia) in old male mice results from diminished activity and availability of TGF-beta [ J ]. J Cell Biochem, 1998,70 (4) : 478-488.
  • 7Mehrara BJ, Saadeh PB, Steinbreeh DS, et al. Adenovirusmediated gene therapy of osteoblasts in vitro and in vivo [J]. J Bone Miner Res,1999,14(8):1290-1301.
  • 8Grainger D J, Percival J, Chiano M, et al. The role of serum TGF-beta isoforms as potential markers of osteoporosis [ J ]. Osteoporos Int, 1999,9(5) : 398404.
  • 9Bord S, Beavan S, Ireland D, et al. Mechanisms by which high-dose estrogen therapy produces anabolic sketetal effects in postmenopausal women:role of locally produced growth factors [J]. Bone,2001,29(3):216-222.
  • 10中国人骨质疏松症建议诊断标准(第二稿)[J].中国骨质疏松杂志,2000,6(1):1-3. 被引量：1235

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  • 1FENGNing-han,WUHong-fei,WUJun,ZHANGWei,SUIYuan-gen,HEHou-guang,ZHANGChun-lei,ZHENGJun-song.Immunology Mechanism of CD4^＋ CD25^ T Regulatory Cells Acting on Effector T Cells[J].Journal of Nanjing Medical University,2004,18(4):178-182. 被引量：28
  • 2杜锡贤,范玉.寻常型进行期银屑病药物治疗进展[J].山东中医杂志,2006,25(1):67-70. 被引量：19
  • 3罗权,林玲,朱慧兰,邓景航,蔡艳霞,何玉清,黄振明,张锡宝.寻常型银屑病患者血清MMP-2、MMP-9水平的动态变化及意义[J].岭南皮肤性病科杂志,2007,14(1):1-3. 被引量：3
  • 4Moll JM, Wrigh TV. Psoriatic arthritis. Semin [ J ]. Arthritis Rheum, 1973,3(1) :55 -78.
  • 5Nakatsukasa H, Tsukimoto M, Tokunaga A, et al. Repeated gamma irra- diation attenuates collagen-induced arthritis via up-regulation of regula- tory T cells but not by damaging lymphocytes directly[ Jl. Radiat Res, 2010,174(3) :313 -24.
  • 6Yamamoto T. 'Psoriatic arthritis: from a dermatological perspective[ J]. Eur J Dermato1,201 1,21 ( 5 ) :660 - 666.
  • 7Sa SM, Valdez PA, Wu J, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis[J]. J Im- muno1,2007,178 (4) :2229 - 2240.
  • 8Lubberts E, Koenders MI, Oppers-Walgreen B, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of colla- gen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion[Jl. Arthritis Rheum,2004,50(2) : 650-659.
  • 9Rosenberg A, Fan H, Chiu YG, et al. Divergent gene activation in peripheral blood and tissues of patients with rheumatoid arthritis, psoriatic arthritis and psoriasis following Infliximab therapy [J]. PLoS One, 2014, 9(10): e110657.
  • 10Ebihara S, Date F, Dong Y, et al. Interleukin-17 is a critical target for the treatment of ankylosing enthesitis and psoriasis-like dermati- tis in mice [J]. Autoimmunity, 2015, 48(4): 259-266.

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中华皮肤科杂志
2011年 第7期

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