二苯乙烯苷的体外稳定性研究

Studies on the stability of stilbene glycoside

目的研究二苯乙烯苷体外稳定性的特征。方法采用高效液相色谱(HPLC)法测定二苯乙烯苷在模拟空腹胃液、模拟进食胃液、模拟小肠液及光照条件下的稳定性。结果体外稳定性实验结果显示,二苯乙烯苷在模拟空腹胃液和模拟小肠液中6 h内分别降解了38.6%和49.5%,光照条件下8 h内降解了61.2%。结论二苯乙烯苷的稳定性比较差,在模拟空腹胃液、模拟小肠液和光照条件下均容易降解。

Objective To study the features of stilbene glycoside＇s stability.Methods The stablity of stilbene glycoside in simulated gastric fluid,simulated small intestinal fluid and illumination was studied by HPLC.Results Stilbene glycoside was unstable in simulated gastric fluid as the pH=1.2,simulated small intestinal fluid and illumination.It degraded 38.6% and 49.5% in simulated gastric fluid and simulated small intestinal fluid respectively at 6 h,degraded 61.2% in illumination at 8 h.Conclusion The stability of Stilbene glycoside is not good.It degrades easily under the conditions of simulated gastric fluid,simulated small intestinal fluid and illumination.