CD147与喉鳞状细胞癌侵袭和转移关系的研究

The study of CD147 with the invasion and metastasis of laryngeal squamous cell carcinoma

目的探讨细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN/CD147)在喉鳞状细胞癌表达及其与肿瘤侵袭和转移的关系。方法采用免疫组织化学染色方法对36例喉鳞状细胞癌、癌旁正常黏膜组织、淋巴结,15例喉乳头状瘤、15例喉息肉标本中CD147表达进行半定量分析。结果喉鳞状细胞癌组表达阳性率为47.2%(17/36),高于喉息肉组[13.3%(2/15)]和癌旁正常黏膜组织组[5.6%(2/36)],与喉鳞状细胞癌T分级、临床分期、淋巴结转移有关(P<0.05)。结论 CD147表达阳性与喉鳞状细胞癌侵袭和转移有关。

Objective To investigate the expression of extracellular matrix metalloproteinase inducer（EMMPRIN/CD147）in laryngeal squamous cell carcinoma,and the relationship with the invasion and metastasis of neoplasms.Methods The expression of CD147 was analyzed semi-quantitatively by immunohistochemical staining in 36 cases of laryngeal squamous cell carcinoma,para-carcinoma normal tissue,and lymph node,15 cases of laryngeal papilloma,and 15 cases of laryngeal polyp.Results The positive rate of expression was 47.2% in laryngeal squamous cell carcinoma,which was higher than in laryngeal polyp（13.3%）or in para-carcinoma normal tissue（5.6%）,and was related with T stage,clinical stage and whether there was lymph node metastasis（P0.05）.Conclusion The positive expression of CD147 has relationship to the invasion and metastasis of laryngeal squamous cell carcinoma.