7种药物治疗寻常型银屑病的成本-效果分析

Cost-effectiveness Analysis of 7 Kinds of Drugs in the Treatment of Psoriasis Vulgaris

目的:评价7种药物治疗寻常型银屑病的经济学效果。方法:221例寻常型银屑病患者随机接受平消胶囊(A组)、吡硫翁锌气雾剂(B组)、他扎罗汀乳膏(C组)、复方青黛胶囊(D组)、百癣夏塔热片(E组)、阿维A胶囊(F组)、卡泊三醇乳膏(G组)治疗,以药物经济学方法进行成本-效果分析。结果:A、B、C、D、E、F、G组的总成本(C)分别为959.83、894.00、1343.50、892.03、832.66、592.02、4664.11元,有效率(E1)分别为65.63%、84.38%、62.50%、66.67%、70.97%、72.73%、80.65%;患者皮损面积及严重程度指数(PASI评分)总分减少量(E2)分别为8.44、11.72、8.25、8.85、9.18、9.74、10.73;平均成本-效果比C/E1分别为1462.49、1059.49、2149.60、1337.98、1173.26、814.00、5783.15,C/E2分别为113.72、76.28、162.85、100.79、90.70、60.78、434.68;与F组比较,A、B、C、D、E、G组增量成本-效果比ΔC/ΔE1分别为-5180.42、2592.10、-7345.85、-4950.66、-13672.73、51415.28,ΔC/ΔE2分别为-282.93、152.52、-504.35、-337.09、-429.71、4113.22。结论:7种药物中,阿维A胶囊治疗寻常型银屑病是较好的治疗方案。

OBJECTIVE：To evaluate the pharmacoeconomics effect of 7 kinds of drugs in the treatment of psoriasis vulgaris. METHODS： 221 patients with psoriasis vulgaris were randomly given Pingxiao capsule （group A）, Pyrithione zinc aerosol （group B）, Tazarotene cream （group C）, Compound qingdai capsules （group D）, Baixuan xiatare tablet （group E）, Acitretin capsules （group F） and Calcipotriol ointment （group G）, respectively. The cost-effectiveness analysis was carried out with pharmacoeconomics. RESULTS： The total costs for group A, B, C, D, E, F, G were 959.83 yuan, 894.00 yuan, 1 343.50 yuan, 892.03 yuan, 832.66 yuan, 592.02 yuan and 4 664.11 yuan, respectively. The effective rates（E1）were 65.63%, 84.38%, 62.50%, 66.67%, 70.97%, 72.73% and 80.65%, respectively. The reduction （E2） in skin lesion area and severity index （PASI scores） were 8.44, 11.72, 8.25, 8.85, 9.18, 9.74 and 10.73, respectively. The average cost-effect ratios C/E1 were 1 462.49, 1 059.49, 2 149.60, 1 337.98, 1 173.26, 814.00 and 5 783.15, respectively; C/E2 were 113.72, 76.28, 162.85, 100.79, 90.70, 60.78 and 434.68, respectively. The increment cost-effect ratios ΔC/ΔE1 of group A, B, C, D, E, G were -5 180.42, 2 592.10, -7 345.85, -4 950.66, -13 672.73 and 51 415.28, respectively; ΔC/ΔE2 were -282.93, 152.52, -504.35, -337.09, -429.71 and 4 113.22, respectively, as compared with group F. CONCLUSION： Acitretin capsule is the optimal drug in the treatment of psoriasis vulgaris among 7 kinds of drugs.