我院2008-2010年ICU院内感染菌株分布及耐药性分析

Distribution of Pathogenic Bacteria of Hospital Infection in ICU and Drug Resistance Analysis in Our Hospital during 2008-2010

目的:了解ICU院内感染病例菌株分布及常用抗菌药物的耐药情况。方法:对我院2008-2010年ICU住院患者各类送检标本细菌培养、分离鉴定和药敏试验结果进行回顾性分析。结果:院内感染病例中共分离出病原菌856株,其中革兰阴性杆菌617株,占72.1%;革兰阳性球菌164株,占19.2%;真菌75株,占8.8%。革兰阴性杆菌对第3、4代头孢菌素耐药率较高,对亚胺培南、哌拉西林/舒巴坦、阿米卡星敏感性较好,亚胺培南总耐药率最低。革兰阳性球菌对万古霉素的耐药率为0%。结论:分离的病原菌以革兰阴性杆菌为主,所占比例有逐年升高趋势,对抗菌药物的耐药率总体上有上升趋势,且耐药性不断发生变化。

OBJECTIVE：To investigate the distribution of pathogenic bacteria of hospital infection in ICU and drug resistance of common antibiotics. METHODS： All the separation identification and drug sensitivity test of pathogens isolated from inpatients with hospital infection from 2008 to 2010 were analyzed retrospectively. RESULTS： 856 pathogenic bacteria were isolated in hospital infection cases of ICU. The main pathogen of nosocomial infection was 617 strains of gram-negative bacteria （72.1%）, 164 strains of gram-positive bacteria （19.2%） and 75 strains of fungi （8.8%） . Drug resistant rate of gram-negative bacteria to 3/4-generation cephalosporins was high, while gram-negative bacteria was sensitive to imipenem, piperacillin/sulbactam sodium and amikacin. Drug resistance rate of gram-negative bacteria to imipenem was the lowest. Drug resistant rate of gram-positive bacteria to vancomycin was 0%. CONCLUSION： Isolated pathogenic bacteria are mainly gram-negative bacteria. The proportion of gram-negative bacteria is rising year by year, and drug resistance of gram-negative bacteria to antibiotics is rising on the whole. Drug resistance of bacteria is constantly changing.