前节OCT与超声角膜测厚仪在角膜内皮移植术后测量中央角膜厚度的比较

Comparison of central corneal thickness measurements between anterior segment-optical co-herence tomography and ultrasonic pachymeter after DSAEK

目的比较角膜内皮移植（DSAEK）术后后眼前节相干光断层扫描（AS—OCT）与超声角膜测厚仪测量的中央角膜厚度（CCT），评估两种方法的一致性，为AS—OCT的临床应用提供客观依据。方法分别应用AS—OCT与超声角膜测厚仪测量DSAEK后患者38例（41只眼）的CCT，对两种方法所得的测量值进行配对t检验及Pearson相关分析，并采用Bland—Altmanplot进行一致性评价。结果AS—OCT与超声角膜测厚仪测量CCT的平均值分别为（728．73±138．39）μm和（718．56-4-131．37）μm；两组数据差异无统计学意义（t=1．170；P=O．249）。通过Pearson相关性分析，这两种方法的测量值成正相关（r=O．916，P〈0．01）。AS—OCT与超声角膜测厚测量值的一致性较好。结论DSAEK后，AS—OCT与超声角膜测厚两种测量方法的一致性较好，但由于前者所具备的独特优势，AS—OCT可以作为DSAEK后长期随访角膜厚度变化的一种有效的检测工具。

Objective To assess the agreement of central corneal thickness （CCT） measured by anterior segment-optical tomography （AS-OCT） and ultrasonic pachymeter after Descemet＇s Stripping with Automated Endothelium Keratoplasty （DSAEK） and provide objective basis for clinical application of AS-OCT. Methods Forty-one eyes of 38 patients after Descemet＇s Stripping with Automated Endothelium Keratoplasty （DSAEK） underwent CCT measurement by AS-OCT and ultrasonic pachymeter. The data was analyzed by paired-t test and Pearson correlation analysis. Bland-Altman plot was used to assess the agreement. Results The mean CCT values were （728.73±138.39）μm measured by AS-OCT and （718.56±131.37）μm measured by ultrasonic pachymeter, and there was no significant difference between the two methods. Regression analysis showed a high correlation between the values obtained by both devices （r =0.916, P 〈0.01）. AS-OCT and ultrasonic pachymeter showed a less agreement in CCT measurement after DSAEK. Conclusions After DSAEK, there is a reasonable agreement between two techniques, AS-OCT and ultrasonic pachymeter of CCT measurements. Considering the special advantages, AS-OCT is an effective method to observe the changes of the corneal thickness in the long term.