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非小细胞肺癌6MV-X射线和10MV-X射线调强放射治疗计划的剂量学比较

Dosimetric comparison of 6MV and 10MV X-ray IMRT plans on non-small-cell lung cancer
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摘要 目的比较非小细胞肺癌(NSCLC)调强放射治疗(IMRT)计划中采用6MV-X和10MV-X射线治疗的剂量学差异。方法应用ADAC Pinnacle8治疗计划系统提供的卷积/迭加法对两种能量条件下相同靶区的IMRT计划进行剂量计算,通过剂量-体积直方图(DVH)参数(最大剂量、平均剂量和处方剂量)、均匀性指数(HI)以及适形指数(CI),比较8例肺癌患者的6MV-X和10MV-X射线的IMRT计划的物理学参数。结果两者靶区的平均剂量、HI和CI之间差异比较无明显统计学差异,但6MV计划中高剂量覆盖靶区的程度优于10MV计划;正常肺组织、心脏、脊髓等危及器官(OAR)的受量基本相同。结论对于肺癌的放射治疗建议选用6MV-X射线。 Objective To compare the effects of 6MV and 10MV X-ray intensity modulated radiotherapy（IMRT） on non-small-cell lung cancer（NSCLC）.Methods 6MV and 10MV X-ray IMRT plans were performed on 8 patients with NSCLC.The doses of the two identical planning objectives of IMRT were calculated by convolution/superposition algorithm provided by ADAC treatment planning system.Plans were compared according to dose-volume histogram（DVH） analysis,including conformity and homogeneity indices（CI and HI）.Results Between 6MV and 10MV X-ray plan,the differences of the average garget dose,HI and CI were not statistically significant（P〉0.05）,but the degree of target coverage in high dose of 6MV plan was better than that in 10MV plan.Conclusions 6MV X-ray plan may be the better choice of radiotherapy on NSCLC.
作者 王磊黎 梁世雄 韦军葆 付庆国 邓烨
机构地区 广西医科大学研究生学院 广西医科大学附属肿瘤医院放疗科
出处 《中国癌症防治杂志》 CAS 2011年第2期133-136,共4页 CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
关键词 调强放射治疗 非小细胞肺癌 剂量均匀性 适形指数 Intensity modulated radiotherapy Non-small-cell lung cancer Dose homogeneity Conformity index
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

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共引文献28

中国癌症防治杂志
2011年 第2期

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