克力芝联合治疗艾滋病患者的临床观察

Clinical observation of lopinair and ritonavir Tablets combination therapy of HIV patients

目的观察克力芝(洛匹那韦/利托那韦)胶囊或片剂联合方案抗病毒疗效及副作用,为临床工作提供参考.方法观察65例成人艾滋病患者因为抗病毒治疗失败或抗病毒药物毒副作用,需要更换为克力芝联合拉米呋定、替诺福韦或齐多夫定方案,观察患者更换前及治疗24周后的体重、血脂、血糖、T细胞亚群、HIV病毒载量的变化以及治疗过程中的不良事件的发生,并进行统计学分析,P<0.05有统计学意义。结果克力芝联合治疗方案对血脂中甘油三酯的影响比较大,前后的均值比较具有显著差异(P<0.05?,高密度脂蛋白的升高具有显著差异(P<0.05?,T细胞亚群和病毒载量的变化具有显著差异,体重无明显变化,10例发生与方案有关的不良事件,发生率为15.3%,症状轻,无需停。结论克力芝联合治疗方案疗效确切,副作用小,对血脂中的甘油三酯影响较大,不良事件的发生率低,临床应用安全。

Objective To observe the Lopinair and RitonavirTablets combination antiviral curative effect and side effects,provide reference for clinical work.Methods To observe 65 patients with adult AIDS patients because antiviral treatment failure or antiviral drug toxicity,need to change to Lopinair/ritonavir Capsules or Tablets and Lamivdine Tablets and Tenofovir or Zidovudine Tablets program,patients were observed before and replace scheme treatment 24 weeks later weight,blood fat and blood sugar,T lymphocyte subsets,the HIV viral and treatment process of adverse events.Results Lopinair and Ritonavir Tablets combination treatments for blood lipid of triglycerides influence is bigger,before and after the mean compare had significant differences,high-density lipoprotein increases with significant difference（P0.05）.T lymphocyte subsets and viral load change had significant differences,weight without apparent change,10 cases occur and plan related adverse events,incidence of 15.3 percent,symptoms light,without stopping drug.Conclusions Lopinair and Ritonavir Tablets combination treatment has definite effect,side effect was small,low incidence of aderse events,clinical application security.