原发性高血压患者动态脉压与靶器官损害的观察

Clinical investgation between pulse pressure of primary hypertention and target organ damages

目的探讨动态脉压与靶器官如颈动脉内膜中层厚度（IMT）、左心室重量指数（LVMI）、血肌酐的相关性。方法将150例高血压患者根据动态脉压不同分组：Ⅰ组,动态脉压≤60mm Hg;Ⅱ组,动态脉压60~80mm Hg;Ⅲ组,动态脉压〉80mm Hg;对所有入选者行颈动脉超声、心脏超声和血肌酐测定。结果 3组原发性高血压患者IMT、LVMI和血肌酐随动态脉压的升高而显著增加,P〈0.05。结论脉压是IMT、左心室肥厚等靶器官的重要危险因素。

Objective To explore the correlation between the pulse pressure of primary hypertention and target organ damages（Intima-media thickness,left ventricular mass index and renal features）.Methods Totally 150 patients diagnosed primary hypertention were assigned 3 groups according to the level of pulse pressures：the pulse pressure is below 60mm Hg,between 60~80mm Hg and above 80mm Hg.All of the select candidates,were taken color ultrasound of cervical arteries ang renal features,we record the Intima-media thickness（IMT） of cervical arteries,left ventricular mass index（LVMI）.Results The IMT,LVMI and renal creatinine raised graduately accompying the level of pulse pressure（P0.05）.Conclusions There were larger corrrlation between the pulse pressure of primary hypertention and target organ damages（Intima-media thickness,left ventricular mass index and renal features）,therefore pulse pressure was a promising indicator in forecasting IMT,LVMI and renal features.