小剂量索他洛尔对老年室性心律失常患者的疗效及其安全性评价

Efficacy and Safety of Low Dose Sotalolin the Treatm entof Aged Patients with Ventricular Arrhythmias

观察了老年室性心律失常患者４２ 例， 以评价索他洛尔 （ｓｏｔａｌｏｌ， ＳＯＴ） 对室性早搏 （室早） 的疗效及安全性。患者服药前后进行了２４ ｈ ＥＫＧ （Ｈｏｌｔｅｒ）、心电图等检查， 发现服ＳＯＴ后２ 周末室早减少≥９０％ 者达２５．０％ ， 减少≥７５％ 者达３０．０％ ， 总有效率为５５．０％ ； ４ 周末室早减少≥９０％ 者达４０．０％ ， 减少≥７５％ 者达１５．０％ ， 总有效率为５５．０％ 。服药前、后ＱＴｃ无明显延长， 血压无明显下降； 但心率减慢， Ｐ＜ ０．０１。ＳＯＴ在４ 周的治疗中未见致心律失常作用。结果提示老年患者服８０～１２０ ｍ ｇ／ｄ 的ＳＯＴ较安全。

Forty-tw o aged patients w ith prem ature ventricular contracts (PVCs) w ere investigated to evaluate the efficacy and safety ofsotalol(SOT) by m eansof24-h EKG (Holter) m onitoring. The patients underw entthe exam inations ofHolterand EKG before and after the adm inistration. Tw o w eeks after oral SOT, the patients w ith PVCs reduction ≥90 % accounted for25.0 % , ≥75 % for 30.0 % w ith the total effective rate being 55.0 % . Four w eeks after oral SOT, the patients w ith PVCs reduction ≥90 % accounted for40.0 % and ≥75 % for 15.0 % w ith the totaleffective rate being 55.0 % . The QTc interval and blood pressure had no significantdecrease, butHRw as decreased from 74.00±8.59 b/m in to 63 75± 3.40 b/m in (P< 0.01) . The proarrhythm ic effects w ere not observed during 4 w eeks. Itw as suggested thatin aged patients w ith PVCs, oralSOT of 80- 120 m g/g w as effective and safe.