肝癌干细胞与肝癌复发转移的研究进展

Advances in understanding the relationship between liver cancer stem cells and metastasis and relapse of liver cancer

影响肝癌预后的因素很多,其中包括确诊时间过晚、合并肝硬化、肿瘤细胞对放化疗不敏感以及术后的转移与复发等.以往对肝癌复发转移的研究重点在:(1)肝癌细胞的脱落、迁移;(2)肝癌细胞在局部组织的黏附;(3)肝癌细胞周围血管的生成.随着对肝癌干细胞的研究报道,使我们对肝癌的转移和复发有了更进一步的认识.本文通过基因层面对肝癌干细胞进行分析,从其来源、信号通路、标志物和治疗方面作一综述.

Many factors may affect the prognosis of liver cancer, including late diagnosis, cirrhosis, and insensitivity of tumor cells to chemotherapy, and postoperative metastasis and relapse. Previous studies on the metastasis and relapse of liver cancer focused mainly on the migration and shedding of liver cancer cells, adhesion of liver cancer cells to surrounding tissue, and generation of peripheral vessels. The advances in research on liver cancer stem cells （LCSCs） have led to a better understanding of the metastasis and relapse of liver cancer. This paper gives a comprehensive review of LCSCs at the genetic level in terms of their origin and surface markers, signaling pathways involved, and treatment implications.