间苯三酚在食管疾病特殊内镜诊治中的应用价值

Clinical application of phloroglucinol in special endoscopic treatment for esophageal diseases

目的:探讨在食管疾病特殊内镜诊治如窄带成像(NBI)染色放大内镜、超声内镜(EUS)检查以及Barrett's食管氩离子凝固(APC)治疗中注射间苯三酚的应用价值.方法:选择因食管疾病如Barrett's食管或早癌等进行NBI染色放大内镜检查、Barrett's食管内镜下行APC术以及EUS术等患者90例,随机分为间苯三酚组和氢溴酸山莨菪碱(654-2)组,比较观察两组间操作时食管痉挛频次与操作时间的差异,并分别观察其不良反应情况.结果:间苯三酚组的食管痉挛频次、操作时间较654-2组显著减少(1.45±0.68次/minvs2.88±1.48次/min;174.77s±48.63svs225.00s±59.48s,均P<0.01);但654-2组较间苯三酚组心率显著增快,且分别有口干(5例)和一过性尿潴留(2例)等不良反应,而间苯三酚组未发现不良反应.结论:间苯三酚能有效缓解食管痉挛,可缩短食管特殊内镜诊治操作时间,且无心悸、口干与尿潴留等不良反应,有推广应用价值.

AIM： To evaluate the application value of Phloroglucinol for Injection in special endoscopic treatment for esophageal diseases, such as narrow-band imaging （NBI） magnifying endoscopy, endoscopic ultrasonography （EUS） and argon plasma coagulation therapy. METHODS： Ninety patients who were willing to accept NBI magnifying endoscopy, EUS or argon plasma coagulation therapy for esophageal diseases （e.g., Barrett’s esophagus or early esophageal cancer） were randomly divided into two groups, one using phloroglucinol and the other using 654-2. The frequency of esophagism, operating time and side effects were compared between the two groups.RESULTS： Compared to the 654-2 group, the frequency of esophagism was significantly lower （1.45 c.p.m ± 0.68 c.p.m vs 2.88 c.p.m ± 1.48 c.p.m, P 0.01） and the operating time was significantly shorter （174.77 s ± 48.63 s vs 225.00 s ± 59.48 s, P 0.01） in the phloroglucinol group. Patients of the 654-2 group developed adverse side effects such as dry mouth （5 cases）, transient urinary retention （2 cases） and obviously increased heart rate, while patients of the phloroglucinol groups did not. CONCLUSION： Phloroglucinol is likely capable of effectively relieving esophagism and shortening the operating time in special endoscopic treatment for esophageal diseases and causes no adverse side effects like increased heart rate, dry mouth and urinary retention.