单纯性肥胖儿童血压变化及其载脂蛋白E基因型多态性对血压的影响

Blood Pressure Changes in Children with Simple Obesity and Effects of Apolipoprotein E Genotype Polymorphism on Blood Pressure

【目的】探讨单纯性肥胖儿童血压的变化及载脂蛋白E基因型多态性对血压的影响。【方法】采用聚合酶链式反应—限制性片段长度多态性方法检测 12 6例单纯性肥胖儿童载脂蛋白E基因型 ,并按常规方法测定血压 ,以健康非肥胖儿童作为对照。【结果】与对照组比较 ,单纯性肥胖儿童收缩压和舒张压明显增高 ,且随肥胖程度的加重而加重。携带ε4等位基因的健康儿童 ,收缩压、舒张压较ε3及ε2等位基因携带者为高 ;而在肥胖儿童 ,ε3等位基因携带者收缩压、舒张压较ε4及ε2等位基因携带者为高。但经统计学处理 ,差异均无显著性。【结论】单纯性肥胖儿童血压增高 ,载脂蛋白E等位基因 (apoε)

Objective To investigate the changes of blood pressure in children with simple obesity and effects of apolipoprotein E(ApoE) genotype polymorphism on blood pressure. Methods Apo E genotypes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in 126 children with simple obesity.Blood pressures were measured by routine methods.The healthy non obese children served as control. Results As compared with blood pressures of the control group,the systolic and diastolic pressures were distinctly higher in obese children.The severer the degree of obesity,the more significant were the abnorma 1ities of blood pressure.In control group,children with apo ε4 allele had higher systolic pressure and diastolic pressure than those with apo ε3 and ε2 alleles;whereas in obese group,higher systolic and diastolic pressures were observed in children with apo ε3 allele than those with apo ε2 and ε4.But there were no statistically significant differences between bothsub groups of obese children. Conclusion The figures of blood pressure were higher in obese children.The levels of blood pressure were not significantly affected by apo ε alleles in either healthy or obese children.