EB病毒ZEBRA lgG抗体变化规律和鼻咽癌发病的关系

The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma

目的 研究ＺＥＢＲＡＩｇＧ 在鼻咽癌癌变不同阶段的动态变化规律。方法 对四会地区鼻咽癌筛查人群的血清库不同时期的标本用ＥＬＩＳＡ 法检测ＺＥＢＲＡＩｇＧ，包括：鼻咽癌２７ 例，高危人群５０ 例，单阳人群５０ 例，全阴人群３０ 例。结果 鼻咽癌组ＺＥＢＲＡｌｇＧ的阳性率为９０－９％ ，高于各对照组，差异均有显著性（Ｐ＜０－０１） 。从ＺＥＢＲＡＩｇＧ出现阳性至病理确诊时的时间平均为３－５（２－６２～４－３８） 年，且至病理确认时抗体水平逐渐升至最高。结论 ＺＥＢＲＡＩｇＧ可作为一个诊断鼻咽癌的指标，抗体持续高水平或抗体水平持续升高者应高度怀疑鼻咽癌。

Objective to explain the change regulation of ZEBRA/IgG in the different state of nasopharyngeal canceration.Methods ZEBRA/IgG were detected in ELISA method to the different state screening samples in suihui area.including:nasopharyngeal carcinoma 27,high risk people 50,VCA/IgA positive person 50,all negative person 30. Results The positive rate of ZEBRA/IgG in the group of NPCwre 90 9%,which is higher than the contrast groups.There is significance between them(P<0 01).The average time from ZEBRA/IgG first positive to be pathonalagly diagnosised is 3 5(2 62 4 38)years and the titer of the antibody gradually rise to the highest level.Conclusion The study suggested that ZEBRA/IgG might be as a diagnosis marker to NPC.The patients whose ZEBRA/IgG consistly keep high or rise should be highly suspected of NPC.