2型糖尿病患者胰岛素抵抗与肾病变及血压的关系——附72例检测报告

Relationships of insulin resistance to diabetic nephropathy and blood pressure in types 2 diabetes

目的： 探讨２ 型糖尿病者胰岛素抵抗（ＩＲ） 与肾病变及血压的关系。方法： 测定７２例２ 型糖尿病伴或不伴肾病变者的胰岛素敏感指数 （葡萄糖利用常数， ＫＩ）、尿清蛋白排泄率 （ＵＡＥＲ）， 进行２４ 小时动态血压监测（ＡＢＰＭ）。结果： 胰岛素敏感指数Ｋ１ 与ＵＡＥＲ呈负相关， 糖尿病肾病变者胰岛素抵抗、血压升高（尤其是夜间血压升高） 及血压昼夜节律异常程度均显著高于不伴肾病变者。结论： 胰岛素抵抗与肾病变及血压升高关系密切，

Objective: To study the relationships of insulin resistance to diabetic nephropathy and blood pressure Methods: Insulin sensitivity index (glucose disposal constant, K I), urinary albumin excretion rate (U AER ) were determined and 24h ambulatory blood pressure were monitored in type 2 diabetes with or without nephropathy Results: K I was negatively related to U AER Patients with diabetic nephropathy had more severe insulin resistance and higher blood pressure (patricularly night blood pressure) compared with those without nephropathy Abnormality of circadian rhythm in blood pressure was also more severe in patients with nephropathy Conclusion: Significant relationships and interplay exist among insulin resistance, diabetic nephropathy and hypertension in type 2 diabetes