摘要
目的制备醋酸氯己定栓剂并建立其质量控制方法。方法以甘油和明胶为辅料,醋酸氯己定为主要成分制备栓剂,采用紫外分光光度法测定醋酸氯己定的含量。结果醋酸氯己定在2~10μg/mL浓度范围内线性关系良好（r=0.999 6）,平均回收率为99.6%,RSD=0.85%（n=9）。结论酸氯己定栓剂制备工艺可行,含量测定方法简便、准确可靠。
Objective To prepare chlorhexidine acetate suppository and establish a method for quality control.Method Gelatin and glycerin were used as the vehicle,Chlorhexidine acetate suppository as main ingredient.The UV-spectrophotometry was used for quantitative analysis.Result The calibration curve of chlorhexidine acetate suppository was linear within a range of 2～10 μg/mL（r=0.999 6）,the average recovery of chlorhexidine acetate suppository was 99.6%,RSD=0.86%（n=9）.Conculsion The chlorhexidine acetate suppository is feasible in technological process.The method of content determination is simple and accurate.
出处
《中南医学科学杂志》
CAS
2011年第2期227-229,共3页
Medical Science Journal of Central South China
关键词
醋酸氯己定
制备
质量控制
chlorhexidine acetate
preparetion
quality control
