普罗帕酮对映体的化学拆分

OPTICAL RESOLUTION AND DETERMINATION OF PROPAFENONE ENANTIOMERS

使普罗帕酮外消旋体与（＋ ）或（－ ）－２，３－二对甲苯酰酒石酸作用，形成非对映异构体盐后分步结晶制备了（Ｒ）－和（Ｓ）－普罗帕酮，得率分别为６２％ 和６０％ 。并采用ＨＰＬＣ柱前手性衍生化法对产品进行了检测，其ｅ．ｅ．均大于９８％ 。

Fractional crystallization was utilized to resolve the enantiomers of propafenone (1) as their diastereomeric salts with 2,3 di O,O′ p toluoyl tartaric acid (yield:(R) 1 62%;(S) 1 60%).The enantiomeric purities of the enantiomers were determined.The enantiomeric excess of (R) 1 as well as (S) 1 was over 98%.