蒲公英水煎剂对蟾蜍离体心脏活动的影响

Effect of Taraacum monglicum Decoction on the Activity of In Vitro Heart of Bufobufo

采用斯氏蛙心插管法和BL-420S智能生物信号显示与处理系统,研究不同浓度蒲公英水煎剂对蟾蜍离体心脏活动的影响。结果表明:与对照组对比,灌流浓度为0.01、0.03、0.05 g/mL的蒲公英水煎剂使离体蛙心心肌收缩力分别下降了1.06%、7.02%和22.15%,蒲公英水煎剂对离体蛙心心肌收缩力具有单向抑制的作用;灌流浓度为0.01、0.03和0.05 g/mL的蒲公英水煎剂对离体蛙心的心率均无显著影响。因此,适当浓度的蒲公英水煎剂可作为临床上减少心输出量和降低血压的中药,另外,也可提取蒲公英中的某些成分制成成药。

Using Sri Lanka＇s frog（Bufobufo） heart intubation method as well as BL-420S intelligent bio-signal display and processing system,the effects of decoction of dandelion（Taraacum monglicum） on the activity of in vitro heart of toad was observed in the present study.The results showed that compared with the control,cardiac contractility of isolated toad heart transfused with either 0.01 g/mL,0.03 g/mL or 0.05 g/mL of dandelion decreased by 1.06%,7.02% and 22.15%,respectively.Dandelion decoction gave an inhibitory effect on the cardiac contractility of isolated toad heart.No significant effects of the tested perfusion concentrations on the heart rate was observed.Therefore,appropriate concentration of dandelion decoction may be prepared as a traditional Chinese medicine to clinically reduce cardiac output and blood pressure.Additionally,some ingredients of the dandelion can also be extracted as the patent medicine.