太赫兹时域光谱技术用于药品检测

Medicine inspection by the terahertz time-domain spectroscopy technique

为研究太赫兹光谱技术用于药品检测的可行性,利用自行搭建的时间扫描太赫兹时域光谱系统对3种不同厂家生产的阿莫西林胶囊进行了测试。测试结果表明,尽管与文献上在氮气环境中获得的结果存在一定差异,但3种样品在太赫兹波段仍然显示出了明显的特征吸收,且不同厂家的药品在吸收峰位置、强度以及折射率谱等方面均有所差别。研究结果证实了太赫兹光谱技术在青霉素类药品的质量监控及在线检测等方面具有广阔的应用前景。

In order to explore the feasibility of medicine inspection by terahertz time-domain spectroscopy technique,3 amoxicillin capsules from 3 different companies were studied by a terahertz time-domain spectroscopy system built by the authors.In spite of certain differences compared with the results from literatures in nitrogen condition,all 3 amoxicillin samples here presented obvious characteristic absorptions.The positions and the amplitudes of the absorption peaks and the refraction indexes of 3 samples were different to one another to some extent.The experiment results confirmed the application prospects of on-line inspection and quality control of penicillin medicines by the terahertz time-domain spectroscopy technique.