儿童实体肿瘤中血管内皮生长因子的表达

Expression of Endothelial Growth Factor in Children with Solid Tumors

目的 探讨血管内皮生长因子在儿童实体肿瘤中表达的意义。方法 对２０ 例肾母细胞瘤和２５ 例神经母细胞瘤，１５ 例对照组标本进行血管内皮生长因子（ＶＥＧＦ）免疫组化分析。结果 ＶＥＧＦ在神经母细胞瘤中的表达阳性为１３ 例（１３／２５） ，在肾母细胞瘤中表达阳性为１２ 例（１２／２０） ，ＶＥＧＦ的表达与肿瘤的临床分期、病理类型无统计学意义，而与肿瘤的转移存在显著性差异（ Ｐ＜０．０５）。对照组阳性为２ 例（２／１５）。结论 ＶＥＧＦ的表达与肿瘤的转移存在密切联系。

Objective To evaluate the expression of vascular endothelial growth factor (VEGF) in children with solid malignant tumors. Methods The specimens from 20 cases with Wilms’ tumor and 25 patients with neuroblastoma were immunostained for VEGF detection. Results VEGF expression was detected in 12( 12/20 ) of Wilms’ tumors and 13( 13/25 ) neuroblastomas. There VEGF expression was no association with the histological type and clinical stage. The VEFG expression rate was significantly higher in tumors from patients with marrow or lung metastasis than those without.Conclusion The study shows that expression of VEFG is in connexion with tumor metastasis.