经支气管镜植入放射性^(125)I粒子治疗中央型肺癌的应用研究

Treatment of central type non-small cell lung cancer with interstitial implantation of ^(125)I seeds by using bronchoscopy

目的探讨经电子支气管镜(EB)直视下植入放射性125I粒子,近距离内照射治疗中央型非小细胞肺癌(NSCLC)的近期效果。方法术前临床和活检证实NSCLC 65例,125I粒子植入联合NP方案化疗(长春瑞滨+顺铂)23例作为实验组,单纯NP方案化疗42例作为对照组。治疗后6个月根据CT和EB检查,比较肿瘤体积,按国际标准判定疗效。结果6个月后实验组和对照组有效率分别为78.2%(18/23)和42.8%(18/42),χ2=92.61,P<0.01。结论放射性125I粒子植入联合化疗是一种有效的、微创的治疗中央型NSCLC的方法。

Objective To evaluate the short-term efficacy of interstitial implantation of 125I seeds by using electronic bronchoscopy（EB） for central type non-small cell lung cancer（NSCLC）.Methods A total of 65 patients with NSCLC were enrolled into this study and divided into two groups.In experimental group（n=23）,the patients received interstitial implantation of 125I combined with NP regimen（NVB＋DDP） chemotherapy.In control group（n=42）,NP regimen chemotherapy was used.Six months after the treatment,the tumor volume in the two groups was measured by using CT and EB.The outcomes of the two groups were compared,and the efficacy of the treatment was evaluated according to the international standards.Result The effective rate was 78.2%（18/23） in the experimental group and 42.8%（18/42） in the control group（χ2=92.61,P〈0.01）.Conclusion Interstitial implantation of 125I seeds combined with chemotherapy is an effective and minimally invasive method for central type NSCLC.